DIPG-27. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION

Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumour for which new treatments are needed. A high throughput drug screen of 3500 pharmaceutical compounds identified anti-malarials, including quinacrine as having potent activity against DIPG neurospheres. CBL01...

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Detalles Bibliográficos
Autores principales: Ehteda, Anahid, Franshaw, Laura, Liu, Jie, Joshi, Swapna, Simon, Sandy, Pang, Chi Nam Ignatius, Giorgi, Federico, Pandher, Ruby, Ung, Caitlin, Tolhurst, Ornella, Mayoh, Chelsea, Khan, Aaminah, Hayden, Elisha, Gopalakrishnan, Anjana, Trebilcock, Peter, Upton, Dannielle, Lehmann, Rebecca, George, Sandra, Vittorio, Orazio, Tsoli, Maria, Gurova, Katerina, Gudkov, Andrei Gudkov, Norris, Murray D, Haber, Michelle, Ziegler, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715505/
http://dx.doi.org/10.1093/neuonc/noaa222.076

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