MBRS-51. MUTATIONS IN BRPF1 FOUND IN SHH MEDULLOBLASTOMA PREVENT INTERACTION WITH TP53 AND LEADS TO RADIORESISTANCE IN VITRO

Medulloblastoma (MB) is one of the most common pediatric tumors in children. Among them, SHH subgroups of MB (MB(SHH)) is characterized by constitutive activation of SHH pathway. Somatic mutations in BRPF1, a chromatin modifier, is found in more than 5% of MB(SHH) and accounts for almost 20% of adul...

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Detalles Bibliográficos
Autores principales: Vouri, Mikaela, Mercier, Audrey, da Silva, Patricia Benites Goncalves, Okonechnikov, Konstantin, Forget, Antoine, Yu, Hua, Chivet, Anais, Kool, Marcel, Pfister, Stefan, Ayrault, Olivier, Kawauchi, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Medulloblastoma (Research)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715508/
http://dx.doi.org/10.1093/neuonc/noaa222.558

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