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MODL-02. TARGETING REPLICATION STRESS IN PEDIATRIC BRAIN TUMORS

Pediatric brain tumors harboring amplifications or high overexpression of MYC-/MYCN are often associated with poor outcome. High MYC(N) expression in these tumors leads to increased transcription, which can be in conflict with DNA replication and subsequently can cause replication stress, R-loops an...

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Detalles Bibliográficos
Autores principales:	Krausert, Sonja, Lambo, Sander, Mack, Norman, Schwalm, Benjamin, Pfister, Stefan, Kool, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Preclinical Models/Experimental Therapy/Drug Discovery
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715544/ http://dx.doi.org/10.1093/neuonc/noaa222.579

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