EPEN-30. C11ORF95-RELA FUSION PROTEIN ENGAGES NOVEL GENOMIC LOCI TO DRIVE MURINE EPENDYMOMA GROWTH

RATIONALE: Over 70% of supratentorial (ST) ependymoma are characterized by an oncogenic fusion between C11ORF95 and RELA. C11ORF95-RELA fusion is frequently the sole genetic driver detected in ST ependymoma, thus ranking this genomic event as a lead target for therapeutic investigation. RELA is a tr...

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Detalles Bibliográficos
Autores principales: Arabzade, Amir, Zhao, Yanhua, Varadharajan, Srinidhi, Chen, Hsiao-Chi, Stuckert, Austin, Rivas, Bryan, Agnihotri, Sameer, Hodges, Courtney, Parsons, Donald, Blaney, Susan, Westbrook, Thomas, Lin, Charles, Yi, Joanna, Deneen, Benjamin, Bertrand, Kelsey, Mack, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Ependymoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715611/
http://dx.doi.org/10.1093/neuonc/noaa222.166

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