DIPG-53. CHARACTERIZING THE ROLE OF PPM1D MUTATIONS IN THE PATHOGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGS)

INTRODUCTION: We have previously found that up to 15% of all DIPGs harbor mutations in PPM1D, resulting in the expression of an activated and truncated PPM1D (PPM1Dtr). Here we evaluate the mechanisms through which PPM1Dtr enhances glioma formation and identify its associated therapeutic vulnerabili...

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Detalles Bibliográficos
Autores principales: Khadka, Prasidda, Reitman, Zachary, Lu, Sophie, Buchan, Graham, Hartley, Rachel, Bear, Heather, Georgis, Yoahnna, Jarmale, Spandana, Schoolcraft, Kathleen, Miller, Peter, Gonzalez, Elizabeth, Gionet, Gabrielle, Qian, Kenin, Melanson, Randy, Keshishian, Hasmik, Carvalho, Diana, Condurat, Alexandra, Goodale, Amy, Abid, Tanaz, Piccioni, Federica, Chi, Susan, Carr, Steven, Haas-Kogan, Daphne, Ebert, Benjamin, Kieran, Mark, Jones, Chris, Ligon, Keith, Beroukhim, Rameen, Phoenix, Timothy, Bandopadhayay, Pratiti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715627/
http://dx.doi.org/10.1093/neuonc/noaa222.098

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