Cargando…
EPEN-01. MULTIDISCIPLINARY TREATMENT IN EPENDYMOMA
BACKGROUND: In intracranial ependymoma, the effectiveness of chemotherapy and radiation therapy is unclear, and the degree of tumor removal contributes to the improvement of life prognosis. METHODS: We examined ependymoma cases treated in our institution from July 1998 to March 2017. RESULTS: There...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715654/ http://dx.doi.org/10.1093/neuonc/noaa222.142 |
_version_ | 1783619006118232064 |
---|---|
author | Hirokawa, Daisuke |
author_facet | Hirokawa, Daisuke |
author_sort | Hirokawa, Daisuke |
collection | PubMed |
description | BACKGROUND: In intracranial ependymoma, the effectiveness of chemotherapy and radiation therapy is unclear, and the degree of tumor removal contributes to the improvement of life prognosis. METHODS: We examined ependymoma cases treated in our institution from July 1998 to March 2017. RESULTS: There were 18 boys and 7 girls. The average age at the time of surgery is 5.3±3.6 years. The pathological diagnosis was Grade II for 8 cases and Grade III for 17 cases. Genetic analysis was performed in 16/25 cases (64%). Of the infratentorial cases, 10/11 cases (90.1%) were PFA and PFB were one case. Of the supratentorial cases, 3/5 cases (60%) were positive for RELA fusion. As chemotherapy, 19 patients were VCR + VP-16 + CDDP + CPA. Irradiation was performed in all cases, local irradiation (50.4–55.8Gy) in 22 cases (88%), and craniospinal irradiation in 2 cases (8%). The 7-year OS was 74.6±9% and the 7-year PFS was 59.7±10.5%. Grade III showed a short OS (p = 0.053). GTR and NTR were obtained in the first excision in 14 cases (56%), and OS and PFS were not significantly different from those in the STR group (p = 0.219, p = 0.248). GTR and NTR including 2nd-look surgery were obtained in 18 cases (72%), and significant improvement of OS was observed compared with STR group (p = 0.02). CONCLUSION: Even if it is not GTR or NTR at the first operation, improvement of OS is expected by total excision after chemotherapy. |
format | Online Article Text |
id | pubmed-7715654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77156542020-12-09 EPEN-01. MULTIDISCIPLINARY TREATMENT IN EPENDYMOMA Hirokawa, Daisuke Neuro Oncol Ependymoma BACKGROUND: In intracranial ependymoma, the effectiveness of chemotherapy and radiation therapy is unclear, and the degree of tumor removal contributes to the improvement of life prognosis. METHODS: We examined ependymoma cases treated in our institution from July 1998 to March 2017. RESULTS: There were 18 boys and 7 girls. The average age at the time of surgery is 5.3±3.6 years. The pathological diagnosis was Grade II for 8 cases and Grade III for 17 cases. Genetic analysis was performed in 16/25 cases (64%). Of the infratentorial cases, 10/11 cases (90.1%) were PFA and PFB were one case. Of the supratentorial cases, 3/5 cases (60%) were positive for RELA fusion. As chemotherapy, 19 patients were VCR + VP-16 + CDDP + CPA. Irradiation was performed in all cases, local irradiation (50.4–55.8Gy) in 22 cases (88%), and craniospinal irradiation in 2 cases (8%). The 7-year OS was 74.6±9% and the 7-year PFS was 59.7±10.5%. Grade III showed a short OS (p = 0.053). GTR and NTR were obtained in the first excision in 14 cases (56%), and OS and PFS were not significantly different from those in the STR group (p = 0.219, p = 0.248). GTR and NTR including 2nd-look surgery were obtained in 18 cases (72%), and significant improvement of OS was observed compared with STR group (p = 0.02). CONCLUSION: Even if it is not GTR or NTR at the first operation, improvement of OS is expected by total excision after chemotherapy. Oxford University Press 2020-12-04 /pmc/articles/PMC7715654/ http://dx.doi.org/10.1093/neuonc/noaa222.142 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Ependymoma Hirokawa, Daisuke EPEN-01. MULTIDISCIPLINARY TREATMENT IN EPENDYMOMA |
title | EPEN-01. MULTIDISCIPLINARY TREATMENT IN EPENDYMOMA |
title_full | EPEN-01. MULTIDISCIPLINARY TREATMENT IN EPENDYMOMA |
title_fullStr | EPEN-01. MULTIDISCIPLINARY TREATMENT IN EPENDYMOMA |
title_full_unstemmed | EPEN-01. MULTIDISCIPLINARY TREATMENT IN EPENDYMOMA |
title_short | EPEN-01. MULTIDISCIPLINARY TREATMENT IN EPENDYMOMA |
title_sort | epen-01. multidisciplinary treatment in ependymoma |
topic | Ependymoma |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715654/ http://dx.doi.org/10.1093/neuonc/noaa222.142 |
work_keys_str_mv | AT hirokawadaisuke epen01multidisciplinarytreatmentinependymoma |