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QOL-18. A LONGITUDINAL STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR
It is well known that neurocognition in children treated for a brain tumor can be affected. However, studies on the trajectory of these neurocognitive problems are scarce. In the present study we investigated the evolution of neurocognition between timepoints of diagnosis, 2, 4 and 6 years later. A...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715696/ http://dx.doi.org/10.1093/neuonc/noaa222.680 |
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author | Lemiere, Jurgen Van den Wyngaert, Linde Vandereydt, Josefien Vandenabeele, Karen Vercruysse, Trui Sleurs, Charlotte Jacobs, Sandra |
author_facet | Lemiere, Jurgen Van den Wyngaert, Linde Vandereydt, Josefien Vandenabeele, Karen Vercruysse, Trui Sleurs, Charlotte Jacobs, Sandra |
author_sort | Lemiere, Jurgen |
collection | PubMed |
description | It is well known that neurocognition in children treated for a brain tumor can be affected. However, studies on the trajectory of these neurocognitive problems are scarce. In the present study we investigated the evolution of neurocognition between timepoints of diagnosis, 2, 4 and 6 years later. A total of 53 children diagnosed with a brain tumor were recruited in this study, of which all completed a comprehensive neuropsychological test battery at three successive timepoints and 30 at 4 timepoints. The first assessment was conducted as soon as possible after diagnosis and before initiation of chemo- and/or radiotherapy. Mean age at diagnosis was 8.06 years. The most common diagnoses were pilocytic astrocytoma (n=28) and medulloblastoma (n=10). 24.5% and 18.9% of these patient groups received focal or craniospinal irradiation, respectively. A repeated measures analysis with cranial irradiation (no, focal, craniospinal) as between-subjects factor demonstrated a significant interaction effect between time and type of irradiation for overall intelligence (p=0.02) for children with three assessments. The same interaction effect was found for overall intelligence and processing speed for children with four assessments (p=.005 and p=.002, respectively). The group who received craniospinal irradiation demonstrated the most pronounced decline. Interestingly, no main time effect or interaction effect was found for general memory functioning. Our results demonstrate that not all neurocognitive functions in children treated for a brain tumor decline after treatment. Overall IQ and processing speed are the most vulnerable outcomes in our cohort, especially for the children treated with craniospinal irradiation. |
format | Online Article Text |
id | pubmed-7715696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77156962020-12-09 QOL-18. A LONGITUDINAL STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR Lemiere, Jurgen Van den Wyngaert, Linde Vandereydt, Josefien Vandenabeele, Karen Vercruysse, Trui Sleurs, Charlotte Jacobs, Sandra Neuro Oncol Neuropsychology/Quality of Life It is well known that neurocognition in children treated for a brain tumor can be affected. However, studies on the trajectory of these neurocognitive problems are scarce. In the present study we investigated the evolution of neurocognition between timepoints of diagnosis, 2, 4 and 6 years later. A total of 53 children diagnosed with a brain tumor were recruited in this study, of which all completed a comprehensive neuropsychological test battery at three successive timepoints and 30 at 4 timepoints. The first assessment was conducted as soon as possible after diagnosis and before initiation of chemo- and/or radiotherapy. Mean age at diagnosis was 8.06 years. The most common diagnoses were pilocytic astrocytoma (n=28) and medulloblastoma (n=10). 24.5% and 18.9% of these patient groups received focal or craniospinal irradiation, respectively. A repeated measures analysis with cranial irradiation (no, focal, craniospinal) as between-subjects factor demonstrated a significant interaction effect between time and type of irradiation for overall intelligence (p=0.02) for children with three assessments. The same interaction effect was found for overall intelligence and processing speed for children with four assessments (p=.005 and p=.002, respectively). The group who received craniospinal irradiation demonstrated the most pronounced decline. Interestingly, no main time effect or interaction effect was found for general memory functioning. Our results demonstrate that not all neurocognitive functions in children treated for a brain tumor decline after treatment. Overall IQ and processing speed are the most vulnerable outcomes in our cohort, especially for the children treated with craniospinal irradiation. Oxford University Press 2020-12-04 /pmc/articles/PMC7715696/ http://dx.doi.org/10.1093/neuonc/noaa222.680 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Neuropsychology/Quality of Life Lemiere, Jurgen Van den Wyngaert, Linde Vandereydt, Josefien Vandenabeele, Karen Vercruysse, Trui Sleurs, Charlotte Jacobs, Sandra QOL-18. A LONGITUDINAL STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR |
title | QOL-18. A LONGITUDINAL STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR |
title_full | QOL-18. A LONGITUDINAL STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR |
title_fullStr | QOL-18. A LONGITUDINAL STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR |
title_full_unstemmed | QOL-18. A LONGITUDINAL STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR |
title_short | QOL-18. A LONGITUDINAL STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR |
title_sort | qol-18. a longitudinal study of neurocognition in children treated for a brain tumor |
topic | Neuropsychology/Quality of Life |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715696/ http://dx.doi.org/10.1093/neuonc/noaa222.680 |
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