MBRS-70. FUNCTIONAL DEPENDENCY BETWEEN REST AND DNMT1 IN MEDULLOBLASTOMA

Medulloblastomas exhibit poor neuronal lineage specification. Expression of RE1 Silencing Transcription Factor (REST), a repressor of neurogenesis, is aberrantly elevated in human sonic hedgehog (SHH) medulloblastomas. Constitutive REST expression in mice (REST(TG)) drives medulloblastoma genesis an...

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Detalles Bibliográficos
Autores principales: Maegawa, Shinji, Dobson, Tara, Lu, Yue, Estecio, Marcos, Harmanci, Arif, Gopalakrishnan, Vidya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Medulloblastoma (Research)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715790/
http://dx.doi.org/10.1093/neuonc/noaa222.574

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