DIPG-79. H3K27M INDUCES EPIGENETIC AND ONCOGENIC CHANGES THAT ARE PARTIALLY REVERSED BY SMALL MOLECULE AURORA KINASE B/C INHIBITION

Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric brain tumor with no curative treatments. Approximately 80% of DIPGs contain an H3K27M mutation. The implications of the mutation and how they may be targeted are not fully understood. We established an H3K27M effect-isolating model by tran...

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Detalles Bibliográficos
Autores principales: Chatwin, Hannah, Lemma, Rakeb, DeSisto, John, Knox, Aaron, Mestnik, Shelby, Reid, Aidan, Vibhakar, Rajeev, Venkataraman, Sujatha, Green, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715821/
http://dx.doi.org/10.1093/neuonc/noaa222.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715821/
http://dx.doi.org/10.1093/neuonc/noaa222.121

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