Cargando…

EPID-03. COMPARISON OF SURVIVAL IN ADULT AND PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA: A 2018 SEER BASED ANALYSIS

Medulloblastoma (MB) is the most common high-grade primary brain malignancy in children and accounts for 1% of adult brain tumors. Previous studies have compared survival in pediatric and adult MB from the National Cancer Institute Surveillance Epidemiology and End Results (SEER) database finding no...

Descripción completa

Detalles Bibliográficos
Autores principales: Moisander-Joyce, Hanna M, Sinha, Anoushka, Fernandez-Ledon, Shannon, Lee, Davon T, Hatano, Satoki, Kahn, Justine, Garvin, James H, Zacharoulis, Stergios, Gartrell-Corrado, Robyn D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715848/
http://dx.doi.org/10.1093/neuonc/noaa222.189
_version_ 1783619051696685056
author Moisander-Joyce, Hanna M
Sinha, Anoushka
Fernandez-Ledon, Shannon
Lee, Davon T
Hatano, Satoki
Kahn, Justine
Garvin, James H
Zacharoulis, Stergios
Gartrell-Corrado, Robyn D
author_facet Moisander-Joyce, Hanna M
Sinha, Anoushka
Fernandez-Ledon, Shannon
Lee, Davon T
Hatano, Satoki
Kahn, Justine
Garvin, James H
Zacharoulis, Stergios
Gartrell-Corrado, Robyn D
author_sort Moisander-Joyce, Hanna M
collection PubMed
description Medulloblastoma (MB) is the most common high-grade primary brain malignancy in children and accounts for 1% of adult brain tumors. Previous studies have compared survival in pediatric and adult MB from the National Cancer Institute Surveillance Epidemiology and End Results (SEER) database finding no difference. However, diagnostic subgroup analyses are limited. We examined survival in children (age 0–19) and adults (20–79) coded as MB in the 2018 SEER database (2000–2016), using Kaplan Meier analysis, log-rank test and Cox proportional hazard ratios (HR) with 95% confidence intervals (CI).). MB in SEER-18 is defined as ICD-O-3 histology codes 9470–9474 (n=1,728). ICD 9473, supratentorial PNET (sPNET, n=97) is biologically distinct so was analyzed separately. 5-year survival for MB, excluding sPNET, was similar in children (n = 1,091, 75.3%) and adults (n= 488, 79.1%) (HR=0.97, CI: 0.79 – 1.17, p=0.50). Subtype analyses showed no survival difference comparing adults and children with desmoplastic nodular MB (n=222, p=0.09), large cell MB (n=73, p=0.46), or MB NOS (n=1330, p=0.10). In contrast, children with sPNET had improved survival (n=65, 72.3%) compared to adults (n=29, 51.7%) (HR = 2.0, CI: 1.10 – 3.92; p=0.02,). In conclusion, 2018 SEER data for MB continue to show no survival difference between adults and children, suggesting adult patients could appropriately be entered on pediatric MB treatment protocols. Further analyses of the 2018 data are ongoing adjusting for sex, race, and treatment. Comparison of adults and children with MB and sPNET will be re-evaluated using the new 2016 World Health Organization classification.
format Online
Article
Text
id pubmed-7715848
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-77158482020-12-09 EPID-03. COMPARISON OF SURVIVAL IN ADULT AND PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA: A 2018 SEER BASED ANALYSIS Moisander-Joyce, Hanna M Sinha, Anoushka Fernandez-Ledon, Shannon Lee, Davon T Hatano, Satoki Kahn, Justine Garvin, James H Zacharoulis, Stergios Gartrell-Corrado, Robyn D Neuro Oncol Epidemiology Medulloblastoma (MB) is the most common high-grade primary brain malignancy in children and accounts for 1% of adult brain tumors. Previous studies have compared survival in pediatric and adult MB from the National Cancer Institute Surveillance Epidemiology and End Results (SEER) database finding no difference. However, diagnostic subgroup analyses are limited. We examined survival in children (age 0–19) and adults (20–79) coded as MB in the 2018 SEER database (2000–2016), using Kaplan Meier analysis, log-rank test and Cox proportional hazard ratios (HR) with 95% confidence intervals (CI).). MB in SEER-18 is defined as ICD-O-3 histology codes 9470–9474 (n=1,728). ICD 9473, supratentorial PNET (sPNET, n=97) is biologically distinct so was analyzed separately. 5-year survival for MB, excluding sPNET, was similar in children (n = 1,091, 75.3%) and adults (n= 488, 79.1%) (HR=0.97, CI: 0.79 – 1.17, p=0.50). Subtype analyses showed no survival difference comparing adults and children with desmoplastic nodular MB (n=222, p=0.09), large cell MB (n=73, p=0.46), or MB NOS (n=1330, p=0.10). In contrast, children with sPNET had improved survival (n=65, 72.3%) compared to adults (n=29, 51.7%) (HR = 2.0, CI: 1.10 – 3.92; p=0.02,). In conclusion, 2018 SEER data for MB continue to show no survival difference between adults and children, suggesting adult patients could appropriately be entered on pediatric MB treatment protocols. Further analyses of the 2018 data are ongoing adjusting for sex, race, and treatment. Comparison of adults and children with MB and sPNET will be re-evaluated using the new 2016 World Health Organization classification. Oxford University Press 2020-12-04 /pmc/articles/PMC7715848/ http://dx.doi.org/10.1093/neuonc/noaa222.189 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Epidemiology
Moisander-Joyce, Hanna M
Sinha, Anoushka
Fernandez-Ledon, Shannon
Lee, Davon T
Hatano, Satoki
Kahn, Justine
Garvin, James H
Zacharoulis, Stergios
Gartrell-Corrado, Robyn D
EPID-03. COMPARISON OF SURVIVAL IN ADULT AND PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA: A 2018 SEER BASED ANALYSIS
title EPID-03. COMPARISON OF SURVIVAL IN ADULT AND PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA: A 2018 SEER BASED ANALYSIS
title_full EPID-03. COMPARISON OF SURVIVAL IN ADULT AND PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA: A 2018 SEER BASED ANALYSIS
title_fullStr EPID-03. COMPARISON OF SURVIVAL IN ADULT AND PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA: A 2018 SEER BASED ANALYSIS
title_full_unstemmed EPID-03. COMPARISON OF SURVIVAL IN ADULT AND PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA: A 2018 SEER BASED ANALYSIS
title_short EPID-03. COMPARISON OF SURVIVAL IN ADULT AND PEDIATRIC PATIENTS WITH MEDULLOBLASTOMA: A 2018 SEER BASED ANALYSIS
title_sort epid-03. comparison of survival in adult and pediatric patients with medulloblastoma: a 2018 seer based analysis
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715848/
http://dx.doi.org/10.1093/neuonc/noaa222.189
work_keys_str_mv AT moisanderjoycehannam epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis
AT sinhaanoushka epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis
AT fernandezledonshannon epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis
AT leedavont epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis
AT hatanosatoki epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis
AT kahnjustine epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis
AT garvinjamesh epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis
AT zacharoulisstergios epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis
AT gartrellcorradorobynd epid03comparisonofsurvivalinadultandpediatricpatientswithmedulloblastomaa2018seerbasedanalysis