EPEN-04. ONCOGENIC 3D TUMOR GENOME ORGANIZATION IDENTIFIES NEW THERAPEUTIC TARGETS IN EPENDYMOMA

By profiling enhancers in primary ependymoma tumors, we have recently identified putative oncogenes, molecular targets, and functional pathways. Inhibition of selected targets diminished the proliferation of patient-derived neurospheres and increased survival in mouse models of ependymoma. While enh...

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Detalles Bibliográficos
Autores principales: Okonechnikov, Konstantin, Hübner, Jens-Martin, Chapman, Owen, Chakraborty, Abhijit, Pagadala, Meghana, Bump, Rosalind, Chandran, Sahaana, Kraft, Katerina, Hidalgo, Rocio Acuna, Mundlos, Stefan, Wechsler-Reya, Robert, Juarez, Edwin F, Coufal, Nicole, Levy, Michael, Crawford, John, Pajtler, Kristian, Reid, Derek, Schmitt, Anthony, Carter, Hannah, Ay, Ferhat, Dixon, Jesse, Mesirov, Jill, Pfister, Stefan M, Kool, Marcel, Chavez, Lukas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Ependymoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715851/
http://dx.doi.org/10.1093/neuonc/noaa222.145

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