EPEN-38. EZH2 INHIBITORY PROTEIN (EZHIP/Cxorf67) EXPRESSION IS HIGHLY CONCORDANT WITH H3K27me3 LOSS AND IS A PROMISING SURROGATE MARKER FOR POSTERIOR FOSSA TYPE A EPENDYMOMAS

BACKGROUND: Gene expression and DNA methylation have identified 2 distinct clinicopathological subgroups among the WHO Grade II/III posterior fossa (PF) ependymomas (EPN), of which the PF-A molecular subgroup associates with poor outcome. OBJECTIVE: To analyse the utility of immunohistochemistry for...

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Detalles Bibliográficos
Autores principales: Nambirajan, Aruna, Rajeshwari, Madhu, Boorgula, Meher, Doddamani, Ramesh, Singh, Manmohan, Garg, Ajay, Suri, Vaishali, Sarkar, Chitra, Sharma, Mehar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Ependymoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715886/
http://dx.doi.org/10.1093/neuonc/noaa222.173

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