Hyaluronic acid in viscous malignant mesothelioma pleural effusion

Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity‐dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (H...

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Autores principales: Cheah, Hui Min, Fitzgerald, Deirdre, Louw, Amber, Creaney, Jenette, Lee, Y. C. Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715921/
https://www.ncbi.nlm.nih.gov/pubmed/33304592
http://dx.doi.org/10.1002/rcr2.694
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author Cheah, Hui Min
Fitzgerald, Deirdre
Louw, Amber
Creaney, Jenette
Lee, Y. C. Gary
author_facet Cheah, Hui Min
Fitzgerald, Deirdre
Louw, Amber
Creaney, Jenette
Lee, Y. C. Gary
author_sort Cheah, Hui Min
collection PubMed
description Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity‐dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight.
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spelling pubmed-77159212020-12-09 Hyaluronic acid in viscous malignant mesothelioma pleural effusion Cheah, Hui Min Fitzgerald, Deirdre Louw, Amber Creaney, Jenette Lee, Y. C. Gary Respirol Case Rep Case Reports Malignant pleural effusion (MPE) is common with mesothelioma. We report two cases of extraordinarily viscous MPEs associated with mesothelioma. The viscosity prohibited spontaneous gravity‐dependent drainage via indwelling pleural catheters. Our ex vivo experiments found very high hyaluronic acid (HA) content within the fluid. Treatment of the fluid with hyaluronidase, but not with deoxyribonucleases, significantly reduced fluid viscosity. The results provide proof that HA can contribute to high viscosity of pleural fluid in mesothelioma. Research into strategies of counteracting HA properties in the management of MPEs may provide further insight. John Wiley & Sons, Ltd 2020-12-03 /pmc/articles/PMC7715921/ /pubmed/33304592 http://dx.doi.org/10.1002/rcr2.694 Text en © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Cheah, Hui Min
Fitzgerald, Deirdre
Louw, Amber
Creaney, Jenette
Lee, Y. C. Gary
Hyaluronic acid in viscous malignant mesothelioma pleural effusion
title Hyaluronic acid in viscous malignant mesothelioma pleural effusion
title_full Hyaluronic acid in viscous malignant mesothelioma pleural effusion
title_fullStr Hyaluronic acid in viscous malignant mesothelioma pleural effusion
title_full_unstemmed Hyaluronic acid in viscous malignant mesothelioma pleural effusion
title_short Hyaluronic acid in viscous malignant mesothelioma pleural effusion
title_sort hyaluronic acid in viscous malignant mesothelioma pleural effusion
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715921/
https://www.ncbi.nlm.nih.gov/pubmed/33304592
http://dx.doi.org/10.1002/rcr2.694
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AT creaneyjenette hyaluronicacidinviscousmalignantmesotheliomapleuraleffusion
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