DIPG-73. SENESCENCE ASSOCIATED SECRETORY PHENOTYPE AS A MECHANISM OF RESISTANCE AND THERAPEUTIC VULNERABILITY IN BMI1 INHIBITOR TREATED DIPG

BACKGROUND: Diffuse intrinsic pontine gliomas (DIPGs) driven by mutations in the histone 3 (H3) gene (H3K27M) are aggressive pediatric brain tumors for which there is no curative therapy. METHODS: To identify novel therapeutic targets we performed a high throughput drug screen combined with an epige...

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Detalles Bibliográficos
Autores principales: Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Bridget, Sanford, Birks, Diane K, Davidson, Nate, Metselaar, Dennis S, Neel, Hans, Donson, Andrew, Griesinger, Andrea, Katagi, Hiroaki, Vijmasi, Trinka, Sola, Ismail, Alimova, Irina, Fosmire, Susan, Hulleman, Esther, Serkova, Natalie J, Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel Montero, Gupta, Nalin, Jones, Ken, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, Venkataraman, Sujatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Diffuse Midline Glioma/DIPG
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715943/
http://dx.doi.org/10.1093/neuonc/noaa222.115

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