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DIPG-39. NOVEL PROTEOMIC ANALYSIS REVEALS EPIGENETIC THERAPEUTIC TARGETS IN PEDIATRIC GLIOMA
INTRODUCTION: Diffuse midline glioma is a highly morbid pediatric cancer. Up to 80% harbor Histone H3K27M mutation, which alters Histone H3 post-translational modifications (PTMs) and genomic enrichment patterns, affecting chromatin structure and transcription. We previously identified tumorigenic p...
Autores principales: | Li, Daphne, Huang, Tina, Camarillo, Jeannie, Piunti, Andrea, Qi, Jin, An, Shejuan, Nazarian, Javad, Thomas, Paul, Saratsis, Amanda |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7715980/ http://dx.doi.org/10.1093/neuonc/noaa222.086 |
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