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Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone
Mycoplasma (M.) bovis is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced susceptibility to reported antimicrobials for this organis...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716209/ https://www.ncbi.nlm.nih.gov/pubmed/33114269 http://dx.doi.org/10.3390/pathogens9110875 |
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author | Tardy, Florence Aspan, Anna Autio, Tiina Ridley, Anne Tricot, Agnès Colin, Adélie Pohjanvirta, Tarja Smid, Bregtje Harders, Frank Lindegaard, Mikkel Tølbøll Lauritsen, Klara Lyhs, Ulrike Wisselink, Henk J. Strube, Mikael Lenz |
author_facet | Tardy, Florence Aspan, Anna Autio, Tiina Ridley, Anne Tricot, Agnès Colin, Adélie Pohjanvirta, Tarja Smid, Bregtje Harders, Frank Lindegaard, Mikkel Tølbøll Lauritsen, Klara Lyhs, Ulrike Wisselink, Henk J. Strube, Mikael Lenz |
author_sort | Tardy, Florence |
collection | PubMed |
description | Mycoplasma (M.) bovis is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced susceptibility to reported antimicrobials for this organism has contributed to difficulties in controlling infection. Despite global presence, some countries have only recently experienced outbreaks of this pathogen. In the present study, M. bovis isolates collected in Denmark between 1981 and 2016 were characterized to determine (i) genetic diversity and phylogenetic relationships using whole genome sequencing and various sequence-based typing methods and (ii) patterns of antimicrobial resistance compared to other European isolates. The M. bovis population in Denmark was found to be highly homogeneous genomically and with respect to the antimicrobial resistance profile. Previously dominated by an old genotype shared by many other countries (ST17 in the PubMLST legacy scheme), a new predominant type represented by ST94-adh1 has emerged. The same clone is also found in Sweden and Finland, where M. bovis introduction is more recent. Although retrieved from the Netherlands, it appears absent from France, two countries with a long history of M. bovis infection where the M. bovis population is more diverse. |
format | Online Article Text |
id | pubmed-7716209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-77162092020-12-05 Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone Tardy, Florence Aspan, Anna Autio, Tiina Ridley, Anne Tricot, Agnès Colin, Adélie Pohjanvirta, Tarja Smid, Bregtje Harders, Frank Lindegaard, Mikkel Tølbøll Lauritsen, Klara Lyhs, Ulrike Wisselink, Henk J. Strube, Mikael Lenz Pathogens Article Mycoplasma (M.) bovis is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced susceptibility to reported antimicrobials for this organism has contributed to difficulties in controlling infection. Despite global presence, some countries have only recently experienced outbreaks of this pathogen. In the present study, M. bovis isolates collected in Denmark between 1981 and 2016 were characterized to determine (i) genetic diversity and phylogenetic relationships using whole genome sequencing and various sequence-based typing methods and (ii) patterns of antimicrobial resistance compared to other European isolates. The M. bovis population in Denmark was found to be highly homogeneous genomically and with respect to the antimicrobial resistance profile. Previously dominated by an old genotype shared by many other countries (ST17 in the PubMLST legacy scheme), a new predominant type represented by ST94-adh1 has emerged. The same clone is also found in Sweden and Finland, where M. bovis introduction is more recent. Although retrieved from the Netherlands, it appears absent from France, two countries with a long history of M. bovis infection where the M. bovis population is more diverse. MDPI 2020-10-23 /pmc/articles/PMC7716209/ /pubmed/33114269 http://dx.doi.org/10.3390/pathogens9110875 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tardy, Florence Aspan, Anna Autio, Tiina Ridley, Anne Tricot, Agnès Colin, Adélie Pohjanvirta, Tarja Smid, Bregtje Harders, Frank Lindegaard, Mikkel Tølbøll Lauritsen, Klara Lyhs, Ulrike Wisselink, Henk J. Strube, Mikael Lenz Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone |
title | Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone |
title_full | Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone |
title_fullStr | Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone |
title_full_unstemmed | Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone |
title_short | Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone |
title_sort | mycoplasma bovis in nordic european countries: emergence and dominance of a new clone |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716209/ https://www.ncbi.nlm.nih.gov/pubmed/33114269 http://dx.doi.org/10.3390/pathogens9110875 |
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