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Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone

Mycoplasma (M.) bovis is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced susceptibility to reported antimicrobials for this organis...

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Autores principales: Tardy, Florence, Aspan, Anna, Autio, Tiina, Ridley, Anne, Tricot, Agnès, Colin, Adélie, Pohjanvirta, Tarja, Smid, Bregtje, Harders, Frank, Lindegaard, Mikkel, Tølbøll Lauritsen, Klara, Lyhs, Ulrike, Wisselink, Henk J., Strube, Mikael Lenz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716209/
https://www.ncbi.nlm.nih.gov/pubmed/33114269
http://dx.doi.org/10.3390/pathogens9110875
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author Tardy, Florence
Aspan, Anna
Autio, Tiina
Ridley, Anne
Tricot, Agnès
Colin, Adélie
Pohjanvirta, Tarja
Smid, Bregtje
Harders, Frank
Lindegaard, Mikkel
Tølbøll Lauritsen, Klara
Lyhs, Ulrike
Wisselink, Henk J.
Strube, Mikael Lenz
author_facet Tardy, Florence
Aspan, Anna
Autio, Tiina
Ridley, Anne
Tricot, Agnès
Colin, Adélie
Pohjanvirta, Tarja
Smid, Bregtje
Harders, Frank
Lindegaard, Mikkel
Tølbøll Lauritsen, Klara
Lyhs, Ulrike
Wisselink, Henk J.
Strube, Mikael Lenz
author_sort Tardy, Florence
collection PubMed
description Mycoplasma (M.) bovis is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced susceptibility to reported antimicrobials for this organism has contributed to difficulties in controlling infection. Despite global presence, some countries have only recently experienced outbreaks of this pathogen. In the present study, M. bovis isolates collected in Denmark between 1981 and 2016 were characterized to determine (i) genetic diversity and phylogenetic relationships using whole genome sequencing and various sequence-based typing methods and (ii) patterns of antimicrobial resistance compared to other European isolates. The M. bovis population in Denmark was found to be highly homogeneous genomically and with respect to the antimicrobial resistance profile. Previously dominated by an old genotype shared by many other countries (ST17 in the PubMLST legacy scheme), a new predominant type represented by ST94-adh1 has emerged. The same clone is also found in Sweden and Finland, where M. bovis introduction is more recent. Although retrieved from the Netherlands, it appears absent from France, two countries with a long history of M. bovis infection where the M. bovis population is more diverse.
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spelling pubmed-77162092020-12-05 Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone Tardy, Florence Aspan, Anna Autio, Tiina Ridley, Anne Tricot, Agnès Colin, Adélie Pohjanvirta, Tarja Smid, Bregtje Harders, Frank Lindegaard, Mikkel Tølbøll Lauritsen, Klara Lyhs, Ulrike Wisselink, Henk J. Strube, Mikael Lenz Pathogens Article Mycoplasma (M.) bovis is an important pathogen of cattle implicated in a broad range of clinical manifestations that adversely impacts livestock production worldwide. In the absence of a safe, effective, commercial vaccine in Europe, reduced susceptibility to reported antimicrobials for this organism has contributed to difficulties in controlling infection. Despite global presence, some countries have only recently experienced outbreaks of this pathogen. In the present study, M. bovis isolates collected in Denmark between 1981 and 2016 were characterized to determine (i) genetic diversity and phylogenetic relationships using whole genome sequencing and various sequence-based typing methods and (ii) patterns of antimicrobial resistance compared to other European isolates. The M. bovis population in Denmark was found to be highly homogeneous genomically and with respect to the antimicrobial resistance profile. Previously dominated by an old genotype shared by many other countries (ST17 in the PubMLST legacy scheme), a new predominant type represented by ST94-adh1 has emerged. The same clone is also found in Sweden and Finland, where M. bovis introduction is more recent. Although retrieved from the Netherlands, it appears absent from France, two countries with a long history of M. bovis infection where the M. bovis population is more diverse. MDPI 2020-10-23 /pmc/articles/PMC7716209/ /pubmed/33114269 http://dx.doi.org/10.3390/pathogens9110875 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tardy, Florence
Aspan, Anna
Autio, Tiina
Ridley, Anne
Tricot, Agnès
Colin, Adélie
Pohjanvirta, Tarja
Smid, Bregtje
Harders, Frank
Lindegaard, Mikkel
Tølbøll Lauritsen, Klara
Lyhs, Ulrike
Wisselink, Henk J.
Strube, Mikael Lenz
Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone
title Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone
title_full Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone
title_fullStr Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone
title_full_unstemmed Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone
title_short Mycoplasma bovis in Nordic European Countries: Emergence and Dominance of a New Clone
title_sort mycoplasma bovis in nordic european countries: emergence and dominance of a new clone
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716209/
https://www.ncbi.nlm.nih.gov/pubmed/33114269
http://dx.doi.org/10.3390/pathogens9110875
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