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Distal and proximal hypoxia response elements co-operate to regulate organ-specific erythropoietin gene expression

While it has been well-established that distal hypoxia response elements (HRE) regulate hypoxia-inducible factor (HIF) target genes such as erythropoietin (Epo), an interplay between multiple distal and proximal (promoter) HRE has not yet been described. Hepatic Epo expression is regulated by an HRE...

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Detalles Bibliográficos
Autores principales:	Orlando, Ilaria M. C., Lafleur, Véronique N., Storti, Federica, Spielmann, Patrick, Crowther, Lisa, Santambrogio, Sara, Schödel, Johannes, Hoogewijs, David, Mole, David R., Wenger, Roland H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716368/ https://www.ncbi.nlm.nih.gov/pubmed/33256376 http://dx.doi.org/10.3324/haematol.2019.236406

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