Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020

A large outbreak of New Delhi metallo-beta-lactamase (NDM)-1-producing Klebsiella pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020, ST147 NDM-9-producing K. pneumoniae were detected at the University Hospital of Pisa, Tuscany, in two critically ill patients; one dev...

Descripción completa

Detalles Bibliográficos
Autores principales: Falcone, Marco, Giordano, Cesira, Barnini, Simona, Tiseo, Giusy, Leonildi, Alessandro, Malacarne, Paolo, Menichetti, Francesco, Carattoli, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716400/
https://www.ncbi.nlm.nih.gov/pubmed/33272354
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.48.2001779
_version_ 1783619152586473472
author Falcone, Marco
Giordano, Cesira
Barnini, Simona
Tiseo, Giusy
Leonildi, Alessandro
Malacarne, Paolo
Menichetti, Francesco
Carattoli, Alessandra
author_facet Falcone, Marco
Giordano, Cesira
Barnini, Simona
Tiseo, Giusy
Leonildi, Alessandro
Malacarne, Paolo
Menichetti, Francesco
Carattoli, Alessandra
author_sort Falcone, Marco
collection PubMed
description A large outbreak of New Delhi metallo-beta-lactamase (NDM)-1-producing Klebsiella pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020, ST147 NDM-9-producing K. pneumoniae were detected at the University Hospital of Pisa, Tuscany, in two critically ill patients; one developed bacteraemia. Genomic and phylogenetic analyses suggest relatedness of 2018–2019 and 2020 strains, with a change from NDM-1 to NDM-9 in the latter and evolution by colistin, tigecycline and fosfomycin resistance acquisition.
format Online
Article
Text
id pubmed-7716400
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher European Centre for Disease Prevention and Control (ECDC)
record_format MEDLINE/PubMed
spelling pubmed-77164002020-12-09 Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020 Falcone, Marco Giordano, Cesira Barnini, Simona Tiseo, Giusy Leonildi, Alessandro Malacarne, Paolo Menichetti, Francesco Carattoli, Alessandra Euro Surveill Rapid Communication A large outbreak of New Delhi metallo-beta-lactamase (NDM)-1-producing Klebsiella pneumoniae sequence type (ST) 147 occurred in Tuscany, Italy in 2018–2019. In 2020, ST147 NDM-9-producing K. pneumoniae were detected at the University Hospital of Pisa, Tuscany, in two critically ill patients; one developed bacteraemia. Genomic and phylogenetic analyses suggest relatedness of 2018–2019 and 2020 strains, with a change from NDM-1 to NDM-9 in the latter and evolution by colistin, tigecycline and fosfomycin resistance acquisition. European Centre for Disease Prevention and Control (ECDC) 2020-12-03 /pmc/articles/PMC7716400/ /pubmed/33272354 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.48.2001779 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Falcone, Marco
Giordano, Cesira
Barnini, Simona
Tiseo, Giusy
Leonildi, Alessandro
Malacarne, Paolo
Menichetti, Francesco
Carattoli, Alessandra
Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
title Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
title_full Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
title_fullStr Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
title_full_unstemmed Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
title_short Extremely drug-resistant NDM-9-producing ST147 Klebsiella pneumoniae causing infections in Italy, May 2020
title_sort extremely drug-resistant ndm-9-producing st147 klebsiella pneumoniae causing infections in italy, may 2020
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716400/
https://www.ncbi.nlm.nih.gov/pubmed/33272354
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.48.2001779
work_keys_str_mv AT falconemarco extremelydrugresistantndm9producingst147klebsiellapneumoniaecausinginfectionsinitalymay2020
AT giordanocesira extremelydrugresistantndm9producingst147klebsiellapneumoniaecausinginfectionsinitalymay2020
AT barninisimona extremelydrugresistantndm9producingst147klebsiellapneumoniaecausinginfectionsinitalymay2020
AT tiseogiusy extremelydrugresistantndm9producingst147klebsiellapneumoniaecausinginfectionsinitalymay2020
AT leonildialessandro extremelydrugresistantndm9producingst147klebsiellapneumoniaecausinginfectionsinitalymay2020
AT malacarnepaolo extremelydrugresistantndm9producingst147klebsiellapneumoniaecausinginfectionsinitalymay2020
AT menichettifrancesco extremelydrugresistantndm9producingst147klebsiellapneumoniaecausinginfectionsinitalymay2020
AT carattolialessandra extremelydrugresistantndm9producingst147klebsiellapneumoniaecausinginfectionsinitalymay2020

Ejemplares similares