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Klotho attenuates angiotensin II-induced cardiotoxicity through suppression of necroptosis and oxidative stress

Hyperglycemia is known to lead to cardiac injury and inflammation through the reactive oxygen species (ROS)-Toll-like receptor 4 (TLR4)-necroptosis pathway. Similarly, angiotensin II (Ang II) activates the TLR4-nuclear factor κB (NF-κB) p65 pathway, while the protein Klotho is known to inhibit this...

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Detalles Bibliográficos
Autores principales:	Yu, Shasha, Yang, Hongmei, Guo, Xiaofan, Sun, Yingxian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716407/ https://www.ncbi.nlm.nih.gov/pubmed/33215215 http://dx.doi.org/10.3892/mmr.2020.11705

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