Targeting the eCIRP/TREM-1 interaction with a small molecule inhibitor improves cardiac dysfunction in neonatal sepsis

BACKGROUND: Neonatal sepsis and the associated myocardial dysfunction remain a leading cause of infant mortality. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a ligand of triggering receptor expressed on myeloid cells-1 (TREM-1). M3 is a small CIRP-derived peptide that inhibits t...

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Detalles Bibliográficos
Autores principales: Denning, Naomi-Liza, Aziz, Monowar, Diao, Li, Prince, Jose M., Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716442/
https://www.ncbi.nlm.nih.gov/pubmed/33276725
http://dx.doi.org/10.1186/s10020-020-00243-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716442/
https://www.ncbi.nlm.nih.gov/pubmed/33276725
http://dx.doi.org/10.1186/s10020-020-00243-6

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