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Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation
BACKGROUND: Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival. METHODS: This retrospective study on kidney transplant...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716446/ https://www.ncbi.nlm.nih.gov/pubmed/33276737 http://dx.doi.org/10.1186/s12882-020-02181-1 |
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author | Chen, Rao Wang, Haifeng Song, Lei Hou, Jianfei Peng, Jiawei Dai, Helong Peng, Longkai |
author_facet | Chen, Rao Wang, Haifeng Song, Lei Hou, Jianfei Peng, Jiawei Dai, Helong Peng, Longkai |
author_sort | Chen, Rao |
collection | PubMed |
description | BACKGROUND: Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival. METHODS: This retrospective study on kidney transplantation was conducted from January 1, 2018, to December 31, 2019, at the Second Xiangya Hospital of Central South University. We classified recipients whose operations were performed in different years into training and validation cohorts and used data from the training cohort to analyze predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors. RESULTS: The incidence rate of DGF was 16.92%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), terminal serum creatine (Scr) concentration, duration of pretransplant dialysis, primary cause of donor death, and usage of LifePort. The internal accuracy of the nomogram was 83.12%. One-year graft survival rates were 93.59 and 99.74%, respectively, for the groups with and without DGF (P < 0.05). CONCLUSION: The nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-020-02181-1. |
format | Online Article Text |
id | pubmed-7716446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77164462020-12-04 Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation Chen, Rao Wang, Haifeng Song, Lei Hou, Jianfei Peng, Jiawei Dai, Helong Peng, Longkai BMC Nephrol Research Article BACKGROUND: Delayed graft function (DGF) is closely associated with the use of marginal donated kidneys due to deficits during transplantation and in recipients. We aimed to predict the incidence of DGF and evaluate its effect on graft survival. METHODS: This retrospective study on kidney transplantation was conducted from January 1, 2018, to December 31, 2019, at the Second Xiangya Hospital of Central South University. We classified recipients whose operations were performed in different years into training and validation cohorts and used data from the training cohort to analyze predictors of DGF. A nomogram was then constructed to predict the likelihood of DGF based on these predictors. RESULTS: The incidence rate of DGF was 16.92%. Binary logistic regression analysis showed correlations between the incidence of DGF and cold ischemic time (CIT), warm ischemic time (WIT), terminal serum creatine (Scr) concentration, duration of pretransplant dialysis, primary cause of donor death, and usage of LifePort. The internal accuracy of the nomogram was 83.12%. One-year graft survival rates were 93.59 and 99.74%, respectively, for the groups with and without DGF (P < 0.05). CONCLUSION: The nomogram established in this study showed good accuracy in predicting DGF after deceased donor kidney transplantation; additionally, DGF decreased one-year graft survival. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12882-020-02181-1. BioMed Central 2020-12-04 /pmc/articles/PMC7716446/ /pubmed/33276737 http://dx.doi.org/10.1186/s12882-020-02181-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Chen, Rao Wang, Haifeng Song, Lei Hou, Jianfei Peng, Jiawei Dai, Helong Peng, Longkai Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation |
title | Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation |
title_full | Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation |
title_fullStr | Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation |
title_full_unstemmed | Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation |
title_short | Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation |
title_sort | predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716446/ https://www.ncbi.nlm.nih.gov/pubmed/33276737 http://dx.doi.org/10.1186/s12882-020-02181-1 |
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