Pharmacological effects of fibroblast growth factor 21 are sex-specific in mice with the lethal yellow (A(y)) mutation

Hypothalamic melanocortin 4 receptors (MC4R) regulate energy balance. Mutations in the MC4R gene are the most common cause of monogenic obesity in humans. Fibroblast growth factor 21 (FGF21) is a promising antiobesity agent, but its effects on melanocortin obesity are unknown. Sex is an important bi...

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Detalles Bibliográficos
Autores principales: Makarova, E.N., Yakovleva, T.V., Balyibina, N.Yu., Baranov, K.O., Denisova, E.I., Dubinina, A.D., Feofanova, N.A., Bazhan, N.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716522/
https://www.ncbi.nlm.nih.gov/pubmed/33659800
http://dx.doi.org/10.18699/VJ20.40-o

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