Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro

It has long been known that defects in the structure of the mitochondrial genome can cause various neuromuscular and neurodegenerative diseases. Nevertheless, at present there is no effective method for treating mitochondrial diseases. The major problem with the treatment of such diseases is associa...

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Detalles Bibliográficos
Autores principales: Zakirova, E.G., Vyatkin, Y.V., Verechshagina, N.A., Muzyka, V.V., Mazunin, I.O., Orishchenko, K.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716540/
https://www.ncbi.nlm.nih.gov/pubmed/33659835
http://dx.doi.org/10.18699/VJ20.643

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