DNMT3A Haploinsufficiency Results in Behavioral Deficits and Global Epigenomic Dysregulation Shared across Neurodevelopmental Disorders

Mutations in DNA methyltransferase 3A (DNMT3A) have been detected in autism and related disorders, but how these mutations disrupt nervous system function is unknown. Here, we define the effects of DNMT3A mutations associated with neurodevelopmental disease. We show that diverse mutations affect dif...

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Detalles Bibliográficos
Autores principales: Christian, Diana L., Wu, Dennis Y., Martin, Jenna R., Moore, J. Russell, Liu, Yiran R., Clemens, Adam W., Nettles, Sabin A., Kirkland, Nicole M., Papouin, Thomas, Hill, Cheryl A., Wozniak, David F., Dougherty, Joseph D., Gabel, Harrison W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716597/
https://www.ncbi.nlm.nih.gov/pubmed/33238114
http://dx.doi.org/10.1016/j.celrep.2020.108416

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