Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine

BACKGROUND AND OBJECTIVE: A novel cocktail containing four substrates of key drug transporters was previously optimized to eliminate mutual drug–drug interactions between the probes digoxin (P-glycoprotein substrate), furosemide (organic anion transporter 1/3), metformin (organic cation transporter...

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Detalles Bibliográficos
Autores principales: Wiebe, Sabrina T., Giessmann, Thomas, Hohl, Kathrin, Schmidt-Gerets, Sven, Hauel, Edith, Jambrecina, Alen, Bader, Kerstin, Ishiguro, Naoki, Taub, Mitchell E., Sharma, Ashish, Ebner, Thomas, Mikus, Gerd, Fromm, Martin F., Müller, Fabian, Stopfer, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716890/
https://www.ncbi.nlm.nih.gov/pubmed/32504272
http://dx.doi.org/10.1007/s40262-020-00907-w

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