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Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls

The coronavirus disease-2019 (COVID-19) pandemic caused by SARS-CoV-2 has exacted an enormous toll on healthcare systems worldwide. The cytokine storm that follows pulmonary infection is causally linked to respiratory compromise and mortality in the majority of patients. The sparsity of viable treat...

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Autores principales: Venkatesulu, Bhanu P, Lester, Scott, Hsieh, Cheng-En, Verma, Vivek, Sharon, Elad, Ahmed, Mansoor, Krishnan, Sunil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717342/
https://www.ncbi.nlm.nih.gov/pubmed/33437924
http://dx.doi.org/10.1093/jncics/pkaa103
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author Venkatesulu, Bhanu P
Lester, Scott
Hsieh, Cheng-En
Verma, Vivek
Sharon, Elad
Ahmed, Mansoor
Krishnan, Sunil
author_facet Venkatesulu, Bhanu P
Lester, Scott
Hsieh, Cheng-En
Verma, Vivek
Sharon, Elad
Ahmed, Mansoor
Krishnan, Sunil
author_sort Venkatesulu, Bhanu P
collection PubMed
description The coronavirus disease-2019 (COVID-19) pandemic caused by SARS-CoV-2 has exacted an enormous toll on healthcare systems worldwide. The cytokine storm that follows pulmonary infection is causally linked to respiratory compromise and mortality in the majority of patients. The sparsity of viable treatment options for this viral infection and the sequelae of pulmonary complications have fueled the quest for new therapeutic considerations. One such option, the long-forgotten idea of using low-dose radiation therapy, has recently found renewed interest in many academic centers. We outline the scientific and logistical rationale for consideration of this option and the mechanistic underpinnings of any potential therapeutic value, particularly as viewed from an immunological perspective. We also discuss the preliminary and/or published results of prospective trials examining low-dose radiation therapy for COVID-19.
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spelling pubmed-77173422020-12-09 Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls Venkatesulu, Bhanu P Lester, Scott Hsieh, Cheng-En Verma, Vivek Sharon, Elad Ahmed, Mansoor Krishnan, Sunil JNCI Cancer Spectr Commentary The coronavirus disease-2019 (COVID-19) pandemic caused by SARS-CoV-2 has exacted an enormous toll on healthcare systems worldwide. The cytokine storm that follows pulmonary infection is causally linked to respiratory compromise and mortality in the majority of patients. The sparsity of viable treatment options for this viral infection and the sequelae of pulmonary complications have fueled the quest for new therapeutic considerations. One such option, the long-forgotten idea of using low-dose radiation therapy, has recently found renewed interest in many academic centers. We outline the scientific and logistical rationale for consideration of this option and the mechanistic underpinnings of any potential therapeutic value, particularly as viewed from an immunological perspective. We also discuss the preliminary and/or published results of prospective trials examining low-dose radiation therapy for COVID-19. Oxford University Press 2020-11-19 /pmc/articles/PMC7717342/ /pubmed/33437924 http://dx.doi.org/10.1093/jncics/pkaa103 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Venkatesulu, Bhanu P
Lester, Scott
Hsieh, Cheng-En
Verma, Vivek
Sharon, Elad
Ahmed, Mansoor
Krishnan, Sunil
Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls
title Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls
title_full Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls
title_fullStr Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls
title_full_unstemmed Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls
title_short Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls
title_sort low-dose radiation therapy for covid-19: promises and pitfalls
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717342/
https://www.ncbi.nlm.nih.gov/pubmed/33437924
http://dx.doi.org/10.1093/jncics/pkaa103
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