AXL Inhibition Enhances MEK Inhibitor Sensitivity in Malignant Peripheral Nerve Sheath Tumors

Dysregulation of the receptor tyrosine kinase AXL is known to promote cancer cell growth and survival in many sarcomas, including the rare subtype, malignant peripheral nerve sheath tumors (MPNST). MPNSTs are largely chemoresistant and carry a poor prognosis. AXL is an attractive potential therapeut...

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Detalles Bibliográficos
Autores principales: Landers, Sharon M., Bhalla, Angela D., Ma, XiaoYan, Lusby, Kristelle, Ingram, Davis, Al Sannaa, Ghadah, Wang, Wei-Lien, Lazar, Alexander J., Torres, Keila E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717506/
https://www.ncbi.nlm.nih.gov/pubmed/33283192
http://dx.doi.org/10.26502/jcsct.5079091

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