Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here. The in vivo studies in a S. mansoni mouse model show...

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Detalles Bibliográficos
Autores principales: Sebastian-Perez, Victor, García-Rubia, Alfonso, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., William, Samia, Blundell, Tom L., Maes, Louis, Martinez, Ana, Campillo, Nuria E., Botros, Sanaa S., Gil, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717570/
https://www.ncbi.nlm.nih.gov/pubmed/31939312
http://dx.doi.org/10.1080/14756366.2020.1712595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717570/
https://www.ncbi.nlm.nih.gov/pubmed/31939312
http://dx.doi.org/10.1080/14756366.2020.1712595

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