Cargando…

The efficacy and safety of Xuebijing injection for corona virus disease 2019: A protocol for a systematic review and meta-analysis

BACKGROUND: Corona virus disease 2019 (COVID-19) is an epidemic respiratory infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 infection. Now it is popular all over the world on a large scale. COVID-19 has the characteristics of rapid transmission, atypical clinical symptom...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Jiaming, Wu, Lili, Ma, Yingying, Liang, Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717801/
https://www.ncbi.nlm.nih.gov/pubmed/33285727
http://dx.doi.org/10.1097/MD.0000000000023401
_version_ 1783619374701084672
author Fu, Jiaming
Wu, Lili
Ma, Yingying
Liang, Qun
author_facet Fu, Jiaming
Wu, Lili
Ma, Yingying
Liang, Qun
author_sort Fu, Jiaming
collection PubMed
description BACKGROUND: Corona virus disease 2019 (COVID-19) is an epidemic respiratory infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 infection. Now it is popular all over the world on a large scale. COVID-19 has the characteristics of rapid transmission, atypical clinical symptoms, easy missed diagnosis and misdiagnosis, and so on. which has seriously affected social and economic development and people's health. Severe acute respiratory syndrome corona virus type 2 infection may lead to systemic cytokine storm, which leads to a sharp deterioration of the condition of ordinary patients. At present, no specific drug has been found in the clinical treatment of covid-19, while Xuebijing injection has been widely used in severe patients in China as a traditional Chinese medicine. The aim of this study is to assess the effificacy and safety of Xuebijing injection for COVID-19. METHODS: Before the research, we conducted a comprehensive search on relevant websites. Two professional researchers will gradually screen, read the title, abstract and full text if necessary, and independently select qualified documents according to the inclusion and exclusion criteria. We will conduct a meta-analysis of the results related to COVID-19 to assess the risks of bias and data extraction. The heterogeneity of data will be studied by Cochrane X(2) and I(2) tests. The evaluation of publication bias will be carried out by funnel chart analysis and Eger test. RESULTS: This review will be disseminated in print by peer-review. CONCLUSION: Our research is to scientifically analyze the clinical evidence of Xuebijing injection in treating severe COVID-19 patients.
format Online
Article
Text
id pubmed-7717801
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-77178012020-12-07 The efficacy and safety of Xuebijing injection for corona virus disease 2019: A protocol for a systematic review and meta-analysis Fu, Jiaming Wu, Lili Ma, Yingying Liang, Qun Medicine (Baltimore) 6700 BACKGROUND: Corona virus disease 2019 (COVID-19) is an epidemic respiratory infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 infection. Now it is popular all over the world on a large scale. COVID-19 has the characteristics of rapid transmission, atypical clinical symptoms, easy missed diagnosis and misdiagnosis, and so on. which has seriously affected social and economic development and people's health. Severe acute respiratory syndrome corona virus type 2 infection may lead to systemic cytokine storm, which leads to a sharp deterioration of the condition of ordinary patients. At present, no specific drug has been found in the clinical treatment of covid-19, while Xuebijing injection has been widely used in severe patients in China as a traditional Chinese medicine. The aim of this study is to assess the effificacy and safety of Xuebijing injection for COVID-19. METHODS: Before the research, we conducted a comprehensive search on relevant websites. Two professional researchers will gradually screen, read the title, abstract and full text if necessary, and independently select qualified documents according to the inclusion and exclusion criteria. We will conduct a meta-analysis of the results related to COVID-19 to assess the risks of bias and data extraction. The heterogeneity of data will be studied by Cochrane X(2) and I(2) tests. The evaluation of publication bias will be carried out by funnel chart analysis and Eger test. RESULTS: This review will be disseminated in print by peer-review. CONCLUSION: Our research is to scientifically analyze the clinical evidence of Xuebijing injection in treating severe COVID-19 patients. Lippincott Williams & Wilkins 2020-12-04 /pmc/articles/PMC7717801/ /pubmed/33285727 http://dx.doi.org/10.1097/MD.0000000000023401 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 6700
Fu, Jiaming
Wu, Lili
Ma, Yingying
Liang, Qun
The efficacy and safety of Xuebijing injection for corona virus disease 2019: A protocol for a systematic review and meta-analysis
title The efficacy and safety of Xuebijing injection for corona virus disease 2019: A protocol for a systematic review and meta-analysis
title_full The efficacy and safety of Xuebijing injection for corona virus disease 2019: A protocol for a systematic review and meta-analysis
title_fullStr The efficacy and safety of Xuebijing injection for corona virus disease 2019: A protocol for a systematic review and meta-analysis
title_full_unstemmed The efficacy and safety of Xuebijing injection for corona virus disease 2019: A protocol for a systematic review and meta-analysis
title_short The efficacy and safety of Xuebijing injection for corona virus disease 2019: A protocol for a systematic review and meta-analysis
title_sort efficacy and safety of xuebijing injection for corona virus disease 2019: a protocol for a systematic review and meta-analysis
topic 6700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717801/
https://www.ncbi.nlm.nih.gov/pubmed/33285727
http://dx.doi.org/10.1097/MD.0000000000023401
work_keys_str_mv AT fujiaming theefficacyandsafetyofxuebijinginjectionforcoronavirusdisease2019aprotocolforasystematicreviewandmetaanalysis
AT wulili theefficacyandsafetyofxuebijinginjectionforcoronavirusdisease2019aprotocolforasystematicreviewandmetaanalysis
AT mayingying theefficacyandsafetyofxuebijinginjectionforcoronavirusdisease2019aprotocolforasystematicreviewandmetaanalysis
AT liangqun theefficacyandsafetyofxuebijinginjectionforcoronavirusdisease2019aprotocolforasystematicreviewandmetaanalysis
AT fujiaming efficacyandsafetyofxuebijinginjectionforcoronavirusdisease2019aprotocolforasystematicreviewandmetaanalysis
AT wulili efficacyandsafetyofxuebijinginjectionforcoronavirusdisease2019aprotocolforasystematicreviewandmetaanalysis
AT mayingying efficacyandsafetyofxuebijinginjectionforcoronavirusdisease2019aprotocolforasystematicreviewandmetaanalysis
AT liangqun efficacyandsafetyofxuebijinginjectionforcoronavirusdisease2019aprotocolforasystematicreviewandmetaanalysis