Cargando…

The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review

The significance of dental materials in dentin-pulp complex tissue engineering is undeniable. The mechanical properties and bioactivity of mineral trioxide aggregate (MTA) make it a promising biomaterial for future stem cell-based endodontic therapies. There are numerous in vitro studies suggesting...

Descripción completa

Detalles Bibliográficos
Autores principales: Babaki, Danial, Yaghoubi, Sanam, Matin, Maryam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717865/
https://www.ncbi.nlm.nih.gov/pubmed/33313519
http://dx.doi.org/10.1080/26415275.2020.1848432
_version_ 1783619389564649472
author Babaki, Danial
Yaghoubi, Sanam
Matin, Maryam M.
author_facet Babaki, Danial
Yaghoubi, Sanam
Matin, Maryam M.
author_sort Babaki, Danial
collection PubMed
description The significance of dental materials in dentin-pulp complex tissue engineering is undeniable. The mechanical properties and bioactivity of mineral trioxide aggregate (MTA) make it a promising biomaterial for future stem cell-based endodontic therapies. There are numerous in vitro studies suggesting the low cytotoxicity of MTA towards various types of cells. Moreover, it has been shown that MTA can enhance mesenchymal stem cells' (MSCs) osteo/odontogenic ability. According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA), a literature review was conducted in the Medline, PubMed, and Scopus databases. Among the identified records, the cytotoxicity and osteo/odontoblastic potential of MTA or its extract on stem cells were investigated. Previous studies have discovered the differentiation-inducing potential of MTA on MSCs, providing a background for dentin-pulp complex cell therapies using the MTA, however, animal trials are needed before moving into clinical trials. In conclusion, MTA can be a promising candidate dental biomaterial for futuristic stem cell-based endodontic therapies.
format Online
Article
Text
id pubmed-7717865
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-77178652020-12-10 The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review Babaki, Danial Yaghoubi, Sanam Matin, Maryam M. Biomater Investig Dent Review Article The significance of dental materials in dentin-pulp complex tissue engineering is undeniable. The mechanical properties and bioactivity of mineral trioxide aggregate (MTA) make it a promising biomaterial for future stem cell-based endodontic therapies. There are numerous in vitro studies suggesting the low cytotoxicity of MTA towards various types of cells. Moreover, it has been shown that MTA can enhance mesenchymal stem cells' (MSCs) osteo/odontogenic ability. According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA), a literature review was conducted in the Medline, PubMed, and Scopus databases. Among the identified records, the cytotoxicity and osteo/odontoblastic potential of MTA or its extract on stem cells were investigated. Previous studies have discovered the differentiation-inducing potential of MTA on MSCs, providing a background for dentin-pulp complex cell therapies using the MTA, however, animal trials are needed before moving into clinical trials. In conclusion, MTA can be a promising candidate dental biomaterial for futuristic stem cell-based endodontic therapies. Taylor & Francis 2020-12-02 /pmc/articles/PMC7717865/ /pubmed/33313519 http://dx.doi.org/10.1080/26415275.2020.1848432 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Babaki, Danial
Yaghoubi, Sanam
Matin, Maryam M.
The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review
title The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review
title_full The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review
title_fullStr The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review
title_full_unstemmed The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review
title_short The effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review
title_sort effects of mineral trioxide aggregate on osteo/odontogenic potential of mesenchymal stem cells: a comprehensive and systematic literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717865/
https://www.ncbi.nlm.nih.gov/pubmed/33313519
http://dx.doi.org/10.1080/26415275.2020.1848432
work_keys_str_mv AT babakidanial theeffectsofmineraltrioxideaggregateonosteoodontogenicpotentialofmesenchymalstemcellsacomprehensiveandsystematicliteraturereview
AT yaghoubisanam theeffectsofmineraltrioxideaggregateonosteoodontogenicpotentialofmesenchymalstemcellsacomprehensiveandsystematicliteraturereview
AT matinmaryamm theeffectsofmineraltrioxideaggregateonosteoodontogenicpotentialofmesenchymalstemcellsacomprehensiveandsystematicliteraturereview
AT babakidanial effectsofmineraltrioxideaggregateonosteoodontogenicpotentialofmesenchymalstemcellsacomprehensiveandsystematicliteraturereview
AT yaghoubisanam effectsofmineraltrioxideaggregateonosteoodontogenicpotentialofmesenchymalstemcellsacomprehensiveandsystematicliteraturereview
AT matinmaryamm effectsofmineraltrioxideaggregateonosteoodontogenicpotentialofmesenchymalstemcellsacomprehensiveandsystematicliteraturereview