Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer’s disease

Myelin degeneration and white matter loss resulting from oligodendrocyte (OL) death are early events in Alzheimer’s disease (AD) that lead to cognitive deficits; however, the underlying mechanism remains unknown. Here, we find that mature OLs in both AD patients and an AD mouse model undergo NLR fam...

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Detalles Bibliográficos
Autores principales: Zhang, Xinwen, Wang, Rihua, Hu, Di, Sun, Xiaoyan, Fujioka, Hisashi, Lundberg, Kathleen, Chan, Ernest R., Wang, Quanqiu, Xu, Rong, Flanagan, Margaret E., Pieper, Andrew A., Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717916/
https://www.ncbi.nlm.nih.gov/pubmed/33277246
http://dx.doi.org/10.1126/sciadv.abb8680

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