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Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function

Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible p...

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Autores principales: Zhu, Bo, Zhu, Lihua, Xia, Lin, Xiong, Yuyun, Yin, Qing, Rui, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717991/
https://www.ncbi.nlm.nih.gov/pubmed/33329564
http://dx.doi.org/10.3389/fimmu.2020.586613
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author Zhu, Bo
Zhu, Lihua
Xia, Lin
Xiong, Yuyun
Yin, Qing
Rui, Ke
author_facet Zhu, Bo
Zhu, Lihua
Xia, Lin
Xiong, Yuyun
Yin, Qing
Rui, Ke
author_sort Zhu, Bo
collection PubMed
description Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible protein post-translational modification process that has emerged as a crucial mechanism that regulates DC maturation and function. Recent studies have shown that ubiquitin enzymes, including E3 ubiquitin ligases and deubiquitinases (DUBs), are pivotal regulators of DC-mediated immune function and serve as potential targets for DC-based immunotherapy of immune-related disorders (e.g., autoimmune disease, infections, and tumors). In this review, we summarize the recent progress regarding the molecular mechanisms and function of ubiquitination in DC-mediated immune homeostasis and immune response.
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spelling pubmed-77179912020-12-15 Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function Zhu, Bo Zhu, Lihua Xia, Lin Xiong, Yuyun Yin, Qing Rui, Ke Front Immunol Immunology Dendritic cells (DCs) are specialized antigen-presenting cells that play a key role in immune homeostasis and the adaptive immune response. DC-induced immune tolerance or activation is strictly dependent on the distinct maturation stages and migration ability of DCs. Ubiquitination is a reversible protein post-translational modification process that has emerged as a crucial mechanism that regulates DC maturation and function. Recent studies have shown that ubiquitin enzymes, including E3 ubiquitin ligases and deubiquitinases (DUBs), are pivotal regulators of DC-mediated immune function and serve as potential targets for DC-based immunotherapy of immune-related disorders (e.g., autoimmune disease, infections, and tumors). In this review, we summarize the recent progress regarding the molecular mechanisms and function of ubiquitination in DC-mediated immune homeostasis and immune response. Frontiers Media S.A. 2020-11-16 /pmc/articles/PMC7717991/ /pubmed/33329564 http://dx.doi.org/10.3389/fimmu.2020.586613 Text en Copyright © 2020 Zhu, Zhu, Xia, Xiong, Yin and Rui http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhu, Bo
Zhu, Lihua
Xia, Lin
Xiong, Yuyun
Yin, Qing
Rui, Ke
Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function
title Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function
title_full Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function
title_fullStr Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function
title_full_unstemmed Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function
title_short Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function
title_sort roles of ubiquitination and deubiquitination in regulating dendritic cell maturation and function
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717991/
https://www.ncbi.nlm.nih.gov/pubmed/33329564
http://dx.doi.org/10.3389/fimmu.2020.586613
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