Cargando…

Metabolomic Analysis of the Ameliorative Effect of Enhanced Proline Metabolism on Hypoxia-Induced Injury in Cardiomyocytes

BACKGROUND: Coronary heart disease is currently the leading cause of death in humans. Its poor prognosis and high mortality are associated with myocardial ischemia, which leads to metabolic disorder-related cardiomyocyte apoptosis and reactive oxygen species (ROS) production. Previous cardiovascular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jiacheng, Xue, Zhimin, Hua, Chunting, Lin, Jun, Shen, Zhida, Song, Yinjing, Ying, Hangying, Lv, Qingbo, Wang, Meihui, Zhou, Binquan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718065/ https://www.ncbi.nlm.nih.gov/pubmed/33294127 http://dx.doi.org/10.1155/2020/8866946

Ejemplares similares

Cardiomyocyte IL-1R2 protects heart from ischemia/reperfusion injury by attenuating IL-17RA-mediated cardiomyocyte apoptosis
por: Lin, Jun, et al.
Publicado: (2022)

Farnesyl diphosphate synthase regulated endothelial proliferation and autophagy during rat pulmonary arterial hypertension induced by monocrotaline
por: Jin, Tingting, et al.
Publicado: (2022)

Overexpression of CyclinA2 ameliorates hypoxia-impaired proliferation of cardiomyocytes
por: DENG, HUILING, et al.
Publicado: (2014)

Protective effect and mechanism of procyanidin B2 against hypoxic injury of cardiomyocytes
por: Xue, Zhimin, et al.
Publicado: (2023)

Identification of differentially expressed genes in the endothelial precursor cells of patients with type 2 diabetes mellitus by bioinformatics analysis
por: Shen, Zhida, et al.
Publicado: (2020)

Metabolomic and transcriptomic studies of improvements in myocardial infarction due to Pycr1 deletion
por: Xue, Zhimin, et al.
Publicado: (2022)

Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis
por: Zhu, Kaiyi, et al.
Publicado: (2021)

Weighted gene co-expression network analysis identified underlying hub genes and mechanisms in the occurrence and development of viral myocarditis
por: Ma, Zetao, et al.
Publicado: (2020)

Metoprolol and bisoprolol ameliorate hypertrophy of neonatal rat cardiomyocytes induced by high glucose via the PKC/NF-κB/c-fos signaling pathway
por: Wang, Min, et al.
Publicado: (2020)

Metoprolol and bisoprolol ameliorate hypertrophy of neonatal rat cardiomyocytes induced by high glucose via the PKC/NF-κB/c-fos signaling pathway
por: Wang, Min, et al.
Publicado: (2022)

Exosomes as a messager to regulate the crosstalk between macrophages and cardiomyocytes under hypoxia conditions
por: Zhang, Zenglei, et al.
Publicado: (2022)

Apelin Ameliorates High Glucose-Induced Downregulation of Connexin 43 via AMPK-Dependent Pathway in Neonatal Rat Cardiomyocytes
por: Li, Xiaoting, et al.
Publicado: (2018)

Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism
por: GUI, LAN, et al.
Publicado: (2016)

miR-3574 ameliorates intermittent hypoxia-induced cardiomyocyte injury through inhibiting Axin1
por: Chen, Qingshi, et al.
Publicado: (2021)

Stachydrine ameliorates hypoxia reoxygenation injury of cardiomyocyte via enhancing SIRT1-Nrf2 pathway
por: Zhu, Xi, et al.
Publicado: (2023)

Integrating Metabolomics and Network Pharmacology to Explore the Mechanism of Tongmai Yangxin Pills in Ameliorating Doxorubicin-Induced Cardiotoxicity
por: Shu, Lexin, et al.
Publicado: (2023)

Development of an LC-MS Targeted Metabolomics Methodology to Study Proline Metabolism in Mammalian Cell Cultures
por: Klupczynska, Agnieszka, et al.
Publicado: (2020)

Hypoxia Induces Cardiomyocyte Proliferation in Humans
por: Ahmed, Mahmoud S., et al.
Publicado: (2020)

Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia
por: Yin, Xue, et al.
Publicado: (2015)

Targeted metabolomics reveals proline as a major osmolyte in the chemolithoautotroph Sulfurimonas denitrificans
por: Götz, Florian, et al.
Publicado: (2018)

N-n-Butyl Haloperidol Iodide Ameliorates Cardiomyocytes Hypoxia/Reoxygenation Injury by Extracellular Calcium-Dependent and -Independent Mechanisms
por: Zhang, Yanmei, et al.
Publicado: (2013)

Digital RNA Sequencing of Human Epidermal Keratinocytes Carrying Human Papillomavirus Type 16 E7
por: Hua, Chunting, et al.
Publicado: (2020)

Autophagy is induced in human keratinocytes during human papillomavirus 11 pseudovirion entry
por: Han, Rui, et al.
Publicado: (2020)

Human Papillomavirus Type 16 Early Protein E7 Activates Autophagy through Inhibition of Dual-Specificity Phosphatase 5
por: Hua, Chunting, et al.
Publicado: (2022)

Gene Expression Profile Analysis of Human Epidermal Keratinocytes Expressing Human Papillomavirus Type 8 E7
por: Chen, Xianzhen, et al.
Publicado: (2022)

Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy
por: Palka, Jerzy, et al.
Publicado: (2021)

Metabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
por: Bhute, Vijesh J., et al.
Publicado: (2017)

Exogenous Proline Improves Salt Tolerance of Alfalfa through Modulation of Antioxidant Capacity, Ion Homeostasis, and Proline Metabolism
por: Guo, Shuaiqi, et al.
Publicado: (2022)

Continuous proline catalysis via leaching of solid proline
por: Opalka, Suzanne M, et al.
Publicado: (2011)

Xinyang Tablet attenuates chronic hypoxia-induced right ventricular remodeling via inhibiting cardiomyocytes apoptosis
por: Gao, An-Ran, et al.
Publicado: (2022)

Myricitrin Protects Cardiomyocytes from Hypoxia/Reoxygenation Injury: Involvement of Heat Shock Protein 90
por: Wang, Min, et al.
Publicado: (2017)

Based on the Metabolomic Approach the Energy Metabolism Responses of Oriental River Prawn Macrobrachium nipponense Hepatopancreas to Acute Hypoxia and Reoxygenation
por: Sun, Shengming, et al.
Publicado: (2018)

Cardiac resident macrophages are involved in hypoxia-induced postnatal cardiomyocyte proliferation
por: Liu, Bo, et al.
Publicado: (2017)

Opa1 Reduces Hypoxia-Induced Cardiomyocyte Death by Improving Mitochondrial Quality Control
por: Xin, Ting, et al.
Publicado: (2020)

Inhibition of Long Noncoding RNA SNHG15 Ameliorates Hypoxia/Ischemia-Induced Neuronal Damage by Regulating miR-302a-3p/STAT1/NF-κB Axis
por: Hu, Chunting, et al.
Publicado: (2021)

Proline-dependent regulation of collagen metabolism
por: Karna, Ewa, et al.
Publicado: (2019)

Proline Metabolism in Neurological and Psychiatric Disorders
por: Yao, Yuxiao, et al.
Publicado: (2022)

Mycorrhizal-Mediated Lower Proline Accumulation in Poncirus trifoliata under Water Deficit Derives from the Integration of Inhibition of Proline Synthesis with Increase of Proline Degradation
por: Zou, Ying-Ning, et al.
Publicado: (2013)

Dissecting the M Phase–specific Phosphorylation of Serine–Proline or Threonine–Proline Motifs
por: Wu, Chuan Fen, et al.
Publicado: (2010)

A mechanochemical approach to access the proline–proline diketopiperazine framework
por: Pétry, Nicolas, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ivllunscp3r9houb66f7cm0g2i