XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis

A distinct 12-hour clock exists in addition to the 24-hour circadian clock to coordinate metabolic and stress rhythms. Here, we show that liver-specific ablation of X-box binding protein 1 (XBP1) disrupts the hepatic 12-hour clock and promotes spontaneous non-alcoholic fatty liver disease (NAFLD). W...

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Detalles Bibliográficos
Autores principales: Meng, Huan, Gonzales, Naomi M., Lonard, David M., Putluri, Nagireddy, Zhu, Bokai, Dacso, Clifford C., York, Brian, O’Malley, Bert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718229/
https://www.ncbi.nlm.nih.gov/pubmed/33277471
http://dx.doi.org/10.1038/s41467-020-20028-z

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