Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver

Ascorbic acid (AA, vitamin C) serves as a cofactor for ten-eleven translocation (TET) enzymes and induces DNA demethylation in vitro. However, its role in DNA demethylation in vivo remains unclear. We previously reported that DNA demethylation in the mouse liver was enhanced during the suckling peri...

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Detalles Bibliográficos
Autores principales: Kawahori, Kenichi, Kondo, Yoshitaka, Yuan, Xunmei, Kawasaki, Yuki, Hanzawa, Nozomi, Tsujimoto, Kazutaka, Wada, Fumiko, Kohda, Takashi, Ishigami, Akihito, Yamada, Tetsuya, Ogawa, Yoshihiro, Hashimoto, Koshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718234/
https://www.ncbi.nlm.nih.gov/pubmed/33277554
http://dx.doi.org/10.1038/s41598-020-77962-7

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