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Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish
The genetic basis of morphological variation provides a major topic in evolutionary developmental biology. Fish of the genus Danio display colour patterns ranging from horizontal stripes, to vertical bars or spots. Stripe formation in zebrafish, Danio rerio, is a self-organizing process based on cel...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718271/ https://www.ncbi.nlm.nih.gov/pubmed/33277491 http://dx.doi.org/10.1038/s41467-020-20021-6 |
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author | Podobnik, Marco Frohnhöfer, Hans Georg Dooley, Christopher M. Eskova, Anastasia Nüsslein-Volhard, Christiane Irion, Uwe |
author_facet | Podobnik, Marco Frohnhöfer, Hans Georg Dooley, Christopher M. Eskova, Anastasia Nüsslein-Volhard, Christiane Irion, Uwe |
author_sort | Podobnik, Marco |
collection | PubMed |
description | The genetic basis of morphological variation provides a major topic in evolutionary developmental biology. Fish of the genus Danio display colour patterns ranging from horizontal stripes, to vertical bars or spots. Stripe formation in zebrafish, Danio rerio, is a self-organizing process based on cell−contact mediated interactions between three types of chromatophores with a leading role of iridophores. Here we investigate genes known to regulate chromatophore interactions in zebrafish that might have evolved to produce a pattern of vertical bars in its sibling species, Danio aesculapii. Mutant D. aesculapii indicate a lower complexity in chromatophore interactions and a minor role of iridophores in patterning. Reciprocal hemizygosity tests identify the potassium channel gene obelix/Kcnj13 as evolved between the two species. Complementation tests suggest evolutionary change through divergence in Kcnj13 function in two additional Danio species. Thus, our results point towards repeated and independent evolution of this gene during colour pattern diversification. |
format | Online Article Text |
id | pubmed-7718271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77182712020-12-07 Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish Podobnik, Marco Frohnhöfer, Hans Georg Dooley, Christopher M. Eskova, Anastasia Nüsslein-Volhard, Christiane Irion, Uwe Nat Commun Article The genetic basis of morphological variation provides a major topic in evolutionary developmental biology. Fish of the genus Danio display colour patterns ranging from horizontal stripes, to vertical bars or spots. Stripe formation in zebrafish, Danio rerio, is a self-organizing process based on cell−contact mediated interactions between three types of chromatophores with a leading role of iridophores. Here we investigate genes known to regulate chromatophore interactions in zebrafish that might have evolved to produce a pattern of vertical bars in its sibling species, Danio aesculapii. Mutant D. aesculapii indicate a lower complexity in chromatophore interactions and a minor role of iridophores in patterning. Reciprocal hemizygosity tests identify the potassium channel gene obelix/Kcnj13 as evolved between the two species. Complementation tests suggest evolutionary change through divergence in Kcnj13 function in two additional Danio species. Thus, our results point towards repeated and independent evolution of this gene during colour pattern diversification. Nature Publishing Group UK 2020-12-04 /pmc/articles/PMC7718271/ /pubmed/33277491 http://dx.doi.org/10.1038/s41467-020-20021-6 Text en © The Author(s) 2020, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Podobnik, Marco Frohnhöfer, Hans Georg Dooley, Christopher M. Eskova, Anastasia Nüsslein-Volhard, Christiane Irion, Uwe Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish |
title | Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish |
title_full | Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish |
title_fullStr | Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish |
title_full_unstemmed | Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish |
title_short | Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish |
title_sort | evolution of the potassium channel gene kcnj13 underlies colour pattern diversification in danio fish |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718271/ https://www.ncbi.nlm.nih.gov/pubmed/33277491 http://dx.doi.org/10.1038/s41467-020-20021-6 |
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