Cargando…
Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat
Neurovascular injury has been proposed as a universal pathological hallmark of traumatic brain injury (TBI) with molecular markers of angiogenesis and endothelial function associated with injury severity and morbidity. Sex differences in the neurovasculature response post-TBI may contribute to the d...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718275/ https://www.ncbi.nlm.nih.gov/pubmed/33277513 http://dx.doi.org/10.1038/s41598-020-77975-2 |
_version_ | 1783619481222774784 |
---|---|
author | Wright, David K. Mayo, Jamie N. Sun, Mujun O’Brien, Terence J. Shultz, Sandy R. |
author_facet | Wright, David K. Mayo, Jamie N. Sun, Mujun O’Brien, Terence J. Shultz, Sandy R. |
author_sort | Wright, David K. |
collection | PubMed |
description | Neurovascular injury has been proposed as a universal pathological hallmark of traumatic brain injury (TBI) with molecular markers of angiogenesis and endothelial function associated with injury severity and morbidity. Sex differences in the neurovasculature response post-TBI may contribute to the differences seen in how males and females respond to injury. Steady-state contrast enhanced magnetic resonance imaging (SSCE-MRI) can be used to non-invasively assess the neurovasculature and may be a useful tool in understanding and predicting outcomes post-TBI. Here we used SSCE-MRI to investigate the neurovasculature of male and female rats at 48 h after an experimental TBI, and how these changes related to neuromotor function at 1-week post-TBI. In addition to TBI induced changes, we found that female rats had greater vessel density, greater cerebral blood volumes and performed better on a neuromotor task than their male counterparts. These results suggest that acute post-TBI cerebrovascular function is worse in males, and that this may contribute to the greater functional deficits observed post-injury. Furthermore, these results highlight the potential of SSCE-MRI to provide insights into the cerebral microvasculature post-TBI. Future studies, incorporating both males and females, are warranted to investigate the evolution of these changes and the underlying mechanisms. |
format | Online Article Text |
id | pubmed-7718275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77182752020-12-08 Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat Wright, David K. Mayo, Jamie N. Sun, Mujun O’Brien, Terence J. Shultz, Sandy R. Sci Rep Article Neurovascular injury has been proposed as a universal pathological hallmark of traumatic brain injury (TBI) with molecular markers of angiogenesis and endothelial function associated with injury severity and morbidity. Sex differences in the neurovasculature response post-TBI may contribute to the differences seen in how males and females respond to injury. Steady-state contrast enhanced magnetic resonance imaging (SSCE-MRI) can be used to non-invasively assess the neurovasculature and may be a useful tool in understanding and predicting outcomes post-TBI. Here we used SSCE-MRI to investigate the neurovasculature of male and female rats at 48 h after an experimental TBI, and how these changes related to neuromotor function at 1-week post-TBI. In addition to TBI induced changes, we found that female rats had greater vessel density, greater cerebral blood volumes and performed better on a neuromotor task than their male counterparts. These results suggest that acute post-TBI cerebrovascular function is worse in males, and that this may contribute to the greater functional deficits observed post-injury. Furthermore, these results highlight the potential of SSCE-MRI to provide insights into the cerebral microvasculature post-TBI. Future studies, incorporating both males and females, are warranted to investigate the evolution of these changes and the underlying mechanisms. Nature Publishing Group UK 2020-12-04 /pmc/articles/PMC7718275/ /pubmed/33277513 http://dx.doi.org/10.1038/s41598-020-77975-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wright, David K. Mayo, Jamie N. Sun, Mujun O’Brien, Terence J. Shultz, Sandy R. Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat |
title | Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat |
title_full | Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat |
title_fullStr | Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat |
title_full_unstemmed | Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat |
title_short | Contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat |
title_sort | contrast enhanced magnetic resonance imaging highlights neurovasculature changes following experimental traumatic brain injury in the rat |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718275/ https://www.ncbi.nlm.nih.gov/pubmed/33277513 http://dx.doi.org/10.1038/s41598-020-77975-2 |
work_keys_str_mv | AT wrightdavidk contrastenhancedmagneticresonanceimaginghighlightsneurovasculaturechangesfollowingexperimentaltraumaticbraininjuryintherat AT mayojamien contrastenhancedmagneticresonanceimaginghighlightsneurovasculaturechangesfollowingexperimentaltraumaticbraininjuryintherat AT sunmujun contrastenhancedmagneticresonanceimaginghighlightsneurovasculaturechangesfollowingexperimentaltraumaticbraininjuryintherat AT obrienterencej contrastenhancedmagneticresonanceimaginghighlightsneurovasculaturechangesfollowingexperimentaltraumaticbraininjuryintherat AT shultzsandyr contrastenhancedmagneticresonanceimaginghighlightsneurovasculaturechangesfollowingexperimentaltraumaticbraininjuryintherat |