The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia

Mutations in the calcium-binding protein calsequestrin cause the highly lethal familial arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In vivo, calsequestrin multimerizes into filaments, but an atomic-resolution structure of a calsequestrin filament is lacking. We report a...

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Detalles Bibliográficos
Autores principales: Titus, Erron W., Deiter, Frederick H., Shi, Chenxu, Wojciak, Julianne, Scheinman, Melvin, Jura, Natalia, Deo, Rahul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718342/
https://www.ncbi.nlm.nih.gov/pubmed/33046906
http://dx.doi.org/10.1038/s41594-020-0510-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718342/
https://www.ncbi.nlm.nih.gov/pubmed/33046906
http://dx.doi.org/10.1038/s41594-020-0510-9

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