Epigenetic Regulation of Wnt Signaling by Carboxamide-Substituted Benzhydryl Amines that Function as Histone Demethylase Inhibitors

Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC). As part of a program to develop epigenetic regulators for cancer therapy, we developed carboxamide-substituted benzhydryl amines (CB...

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Detalles Bibliográficos
Autores principales: Zhang, Wen, Sviripa, Vitaliy M., Xie, Yanqi, Yu, Tianxin, Haney, Meghan G., Blackburn, Jessica S., Adeniran, Charles A., Zhan, Chang-Guo, Watt, David S., Liu, Chunming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718485/
https://www.ncbi.nlm.nih.gov/pubmed/33305174
http://dx.doi.org/10.1016/j.isci.2020.101795

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