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Injury of the optic radiation in patients with mild TBI: A DTT study

OBJECTIVES: We investigated injuries of the optic radiations (ORs) in patients with mild traumatic brain injury (TBI) by using diffusion tensor tractography (DTT). METHODS: Fifty-two consecutive patients who complained of visual problems showed abnormal visual evoked potential (VEP) latency but no a...

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Autores principales: Jang, Sung Ho, Kim, Seong Ho, Seo, You Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718621/
https://www.ncbi.nlm.nih.gov/pubmed/33335773
http://dx.doi.org/10.1515/tnsci-2020-0108
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author Jang, Sung Ho
Kim, Seong Ho
Seo, You Sung
author_facet Jang, Sung Ho
Kim, Seong Ho
Seo, You Sung
author_sort Jang, Sung Ho
collection PubMed
description OBJECTIVES: We investigated injuries of the optic radiations (ORs) in patients with mild traumatic brain injury (TBI) by using diffusion tensor tractography (DTT). METHODS: Fifty-two consecutive patients who complained of visual problems showed abnormal visual evoked potential (VEP) latency but no abnormality on conventional brain MRI after mild TBI, and fifty normal control subjects were recruited for this study. Subjects’ ORs were reconstructed using DTT, and three DTT parameters (fractional anisotropy [FA], apparent diffusion coefficient [ADC], and tract volume) were measured for each OR. RESULTS: Mean FA value and tract volume of the OR were significantly lower in the patient group than in the control group (p < 0.05). However, there was no significant difference in the ADC values of the OR between the patient and control groups (p > 0.05). A weak negative correlation was detected between VEP latency and OR fiber number (r = 0.204, p < 0.05). CONCLUSIONS: DTT revealed that OR injuries were not detected on the conventional brain MRI scans of patients who complained of visual problems and had abnormal VEP latency after mild TBI. Our results suggest that DTT would be a useful technique for detecting OR injury in patients with mild TBI.
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spelling pubmed-77186212020-12-16 Injury of the optic radiation in patients with mild TBI: A DTT study Jang, Sung Ho Kim, Seong Ho Seo, You Sung Transl Neurosci Research Article OBJECTIVES: We investigated injuries of the optic radiations (ORs) in patients with mild traumatic brain injury (TBI) by using diffusion tensor tractography (DTT). METHODS: Fifty-two consecutive patients who complained of visual problems showed abnormal visual evoked potential (VEP) latency but no abnormality on conventional brain MRI after mild TBI, and fifty normal control subjects were recruited for this study. Subjects’ ORs were reconstructed using DTT, and three DTT parameters (fractional anisotropy [FA], apparent diffusion coefficient [ADC], and tract volume) were measured for each OR. RESULTS: Mean FA value and tract volume of the OR were significantly lower in the patient group than in the control group (p < 0.05). However, there was no significant difference in the ADC values of the OR between the patient and control groups (p > 0.05). A weak negative correlation was detected between VEP latency and OR fiber number (r = 0.204, p < 0.05). CONCLUSIONS: DTT revealed that OR injuries were not detected on the conventional brain MRI scans of patients who complained of visual problems and had abnormal VEP latency after mild TBI. Our results suggest that DTT would be a useful technique for detecting OR injury in patients with mild TBI. De Gruyter 2020-09-21 /pmc/articles/PMC7718621/ /pubmed/33335773 http://dx.doi.org/10.1515/tnsci-2020-0108 Text en © 2020 Sung Ho Jang et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Jang, Sung Ho
Kim, Seong Ho
Seo, You Sung
Injury of the optic radiation in patients with mild TBI: A DTT study
title Injury of the optic radiation in patients with mild TBI: A DTT study
title_full Injury of the optic radiation in patients with mild TBI: A DTT study
title_fullStr Injury of the optic radiation in patients with mild TBI: A DTT study
title_full_unstemmed Injury of the optic radiation in patients with mild TBI: A DTT study
title_short Injury of the optic radiation in patients with mild TBI: A DTT study
title_sort injury of the optic radiation in patients with mild tbi: a dtt study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718621/
https://www.ncbi.nlm.nih.gov/pubmed/33335773
http://dx.doi.org/10.1515/tnsci-2020-0108
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