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Advances in the role of miRNAs in the occurrence and development of osteosarcoma

Osteosarcoma (OS) is the most common primary malignant tumor of the skeletal system in the clinic. It mainly occurs in adolescent patients and the pathogenesis of the disease is very complicated. The distant metastasis may occur in the early stage, and the prognosis is poor. MicroRNAs (miRNAs) are n...

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Autores principales: Zhang, Guanyu, Li, Yiran, Xu, Jiasheng, Xiong, Zhenfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718646/
https://www.ncbi.nlm.nih.gov/pubmed/33336056
http://dx.doi.org/10.1515/med-2020-0205
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author Zhang, Guanyu
Li, Yiran
Xu, Jiasheng
Xiong, Zhenfang
author_facet Zhang, Guanyu
Li, Yiran
Xu, Jiasheng
Xiong, Zhenfang
author_sort Zhang, Guanyu
collection PubMed
description Osteosarcoma (OS) is the most common primary malignant tumor of the skeletal system in the clinic. It mainly occurs in adolescent patients and the pathogenesis of the disease is very complicated. The distant metastasis may occur in the early stage, and the prognosis is poor. MicroRNAs (miRNAs) are non-coding RNAs of about 18–25 nt in length that are involved in post-transcriptional regulation of genes. miRNAs can regulate target gene expression by promoting the degradation of target mRNAs or inhibiting the translation process, thereby the proliferation of OS cells can be inhibited and the apoptosis can be promoted; in this way, miRNAs can affect the metabolism of OS cells and can also participate in the occurrence, invasion, metastasis, and recurrence of OS. Some miRNAs have already been found to be closely related to the prognosis of patients with OS. Unlike other reviews, this review summarizes the miRNA molecules closely related to the development, diagnosis, prognosis, and treatment of OS in recent years. The expression and influence of miRNA molecule on OS were discussed in detail, and the related research progress was summarized to provide a new research direction for early diagnosis and treatment of OS.
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spelling pubmed-77186462020-12-16 Advances in the role of miRNAs in the occurrence and development of osteosarcoma Zhang, Guanyu Li, Yiran Xu, Jiasheng Xiong, Zhenfang Open Med (Wars) Research Article Osteosarcoma (OS) is the most common primary malignant tumor of the skeletal system in the clinic. It mainly occurs in adolescent patients and the pathogenesis of the disease is very complicated. The distant metastasis may occur in the early stage, and the prognosis is poor. MicroRNAs (miRNAs) are non-coding RNAs of about 18–25 nt in length that are involved in post-transcriptional regulation of genes. miRNAs can regulate target gene expression by promoting the degradation of target mRNAs or inhibiting the translation process, thereby the proliferation of OS cells can be inhibited and the apoptosis can be promoted; in this way, miRNAs can affect the metabolism of OS cells and can also participate in the occurrence, invasion, metastasis, and recurrence of OS. Some miRNAs have already been found to be closely related to the prognosis of patients with OS. Unlike other reviews, this review summarizes the miRNA molecules closely related to the development, diagnosis, prognosis, and treatment of OS in recent years. The expression and influence of miRNA molecule on OS were discussed in detail, and the related research progress was summarized to provide a new research direction for early diagnosis and treatment of OS. De Gruyter 2020-10-12 /pmc/articles/PMC7718646/ /pubmed/33336056 http://dx.doi.org/10.1515/med-2020-0205 Text en © 2020 Guanyu Zhang et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Zhang, Guanyu
Li, Yiran
Xu, Jiasheng
Xiong, Zhenfang
Advances in the role of miRNAs in the occurrence and development of osteosarcoma
title Advances in the role of miRNAs in the occurrence and development of osteosarcoma
title_full Advances in the role of miRNAs in the occurrence and development of osteosarcoma
title_fullStr Advances in the role of miRNAs in the occurrence and development of osteosarcoma
title_full_unstemmed Advances in the role of miRNAs in the occurrence and development of osteosarcoma
title_short Advances in the role of miRNAs in the occurrence and development of osteosarcoma
title_sort advances in the role of mirnas in the occurrence and development of osteosarcoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718646/
https://www.ncbi.nlm.nih.gov/pubmed/33336056
http://dx.doi.org/10.1515/med-2020-0205
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