Characterization of novel neutralizing mouse monoclonal antibody JM1-24-3 developed against MUC18 in metastatic melanoma

BACKGROUND: MUC18 is a glycoprotein highly expressed on the surface of melanoma and other cancers which promotes tumor progression and metastasis. However, its mechanism of action and suitability as a therapeutic target are unknown. METHODS: A monoclonal antibody (mAb) (JM1-24-3) was generated from...

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Detalles Bibliográficos
Autores principales: Feng, Runhua, Wang, Yuling, Ramachandran, Vijaya, Ma, Qinhong, May, Matthew M., Li, Ming, Zhou, Joe X., Xu, Xiang, Xu, Kejing, Fang, Shenying, Xia, Weiya, Sui, Dawen, Liu, Huey, Gao, Xiaolian, Prieto, Victor, Blacklow, Stephen C., Lu, Mason, Lee, Jeffrey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718695/
https://www.ncbi.nlm.nih.gov/pubmed/33278894
http://dx.doi.org/10.1186/s13046-020-01722-8

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