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Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma

Up-regulation of Uridine-cytidine kinase 2 (UCK2), a rate-limiting enzyme of the pyrimidine salvage pathway, has been suggested in HCC, but the detailed molecular mechanisms and therapic role of UCK2 remain elusive. Bioinformatic analyses revealed that UCK2 might be a key up-regulated metabolic gene...

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Detalles Bibliográficos
Autores principales:	Cai, Jie, Sun, Xuehua, Guo, Han, Qu, Xiaoye, Huang, Hongting, Yu, Chang, Wu, Hailong, Gao, Yueqiu, Kong, Xiaoni, Xia, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718876/ https://www.ncbi.nlm.nih.gov/pubmed/33277463 http://dx.doi.org/10.1038/s41389-020-00287-7

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