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Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment
Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of developing mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the alterations in spontaneous brain activity and network connectivity through regional homogene...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718881/ https://www.ncbi.nlm.nih.gov/pubmed/33277510 http://dx.doi.org/10.1038/s41598-020-76495-3 |
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author | Xiong, Ying Chen, Xiaodan Zhao, Xu Fan, Yang Zhang, Qiang Zhu, Wenzhen |
author_facet | Xiong, Ying Chen, Xiaodan Zhao, Xu Fan, Yang Zhang, Qiang Zhu, Wenzhen |
author_sort | Xiong, Ying |
collection | PubMed |
description | Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of developing mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the alterations in spontaneous brain activity and network connectivity through regional homogeneity (ReHo) and graph theoretical network analyses, respectively, of resting-state functional Magnetic Resonance Imaging (rs-fMRI) in T2DM patients with and without MCI, so as to facilitate early diagnose. Twenty-five T2DM patients with MCI (DM-MCI), 25 T2DM patients with normal cognition (DM-NC), 27 healthy controls were enrolled. Whole-brain ReHo values were calculated and topological properties of functional networks were analyzed. The DM-MCI group exhibited decreased ReHo in the left inferior/middle occipital gyrus and right inferior temporal gyrus, and increased ReHo in frontal gyrus compared to the DM-NCs. Significant correlations were found between ReHo values and clinical measurements. The DM-MCI group illustrated greater clustering coefficient/local efficiency and altered nodal characteristics (efficiency, degree and betweenness), which increased in certain occipital, temporal and parietal regions but decreased in the right inferior temporal gyrus, compared to the DM-NCs. The altered ReHo and impaired network organization may underlie the impaired cognitive functions in T2DM and suggesting a compensation mechanism. These rs-fMRI measures have the potential as biomarkers of disease progression in diabetic encephalopathy. |
format | Online Article Text |
id | pubmed-7718881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77188812020-12-08 Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment Xiong, Ying Chen, Xiaodan Zhao, Xu Fan, Yang Zhang, Qiang Zhu, Wenzhen Sci Rep Article Patients with Type-2 Diabetes Mellitus (T2DM) have a considerably higher risk of developing mild cognitive impairment (MCI) and dementia. The initial symptoms are very insidious at onset. We investigated the alterations in spontaneous brain activity and network connectivity through regional homogeneity (ReHo) and graph theoretical network analyses, respectively, of resting-state functional Magnetic Resonance Imaging (rs-fMRI) in T2DM patients with and without MCI, so as to facilitate early diagnose. Twenty-five T2DM patients with MCI (DM-MCI), 25 T2DM patients with normal cognition (DM-NC), 27 healthy controls were enrolled. Whole-brain ReHo values were calculated and topological properties of functional networks were analyzed. The DM-MCI group exhibited decreased ReHo in the left inferior/middle occipital gyrus and right inferior temporal gyrus, and increased ReHo in frontal gyrus compared to the DM-NCs. Significant correlations were found between ReHo values and clinical measurements. The DM-MCI group illustrated greater clustering coefficient/local efficiency and altered nodal characteristics (efficiency, degree and betweenness), which increased in certain occipital, temporal and parietal regions but decreased in the right inferior temporal gyrus, compared to the DM-NCs. The altered ReHo and impaired network organization may underlie the impaired cognitive functions in T2DM and suggesting a compensation mechanism. These rs-fMRI measures have the potential as biomarkers of disease progression in diabetic encephalopathy. Nature Publishing Group UK 2020-12-04 /pmc/articles/PMC7718881/ /pubmed/33277510 http://dx.doi.org/10.1038/s41598-020-76495-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xiong, Ying Chen, Xiaodan Zhao, Xu Fan, Yang Zhang, Qiang Zhu, Wenzhen Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment |
title | Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment |
title_full | Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment |
title_fullStr | Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment |
title_full_unstemmed | Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment |
title_short | Altered regional homogeneity and functional brain networks in Type 2 diabetes with and without mild cognitive impairment |
title_sort | altered regional homogeneity and functional brain networks in type 2 diabetes with and without mild cognitive impairment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718881/ https://www.ncbi.nlm.nih.gov/pubmed/33277510 http://dx.doi.org/10.1038/s41598-020-76495-3 |
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