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Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo

This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio frequency data telemetry link with 2 Mbps (p...

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Autores principales: Keramatzadeh, Keivan, Kiakojouri, Ali, Nahvi, Mohammad Sadegh, Khazaei, Yousef, Feizi-nejad, Ali, Maghami, Mohammad Hossein, Mohammadi, Reza, Sharifshazileh, Mohammadali, Nasiri, Soraya, Akbari Boroumand, Farhad, Nadimi, Ebrahim, Rezaei, Mahmoud, Shojaei, Amir, Mirnajafi-Zadeh, Javad, Sodagar, Amir M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718888/
https://www.ncbi.nlm.nih.gov/pubmed/33277523
http://dx.doi.org/10.1038/s41598-020-77953-8
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author Keramatzadeh, Keivan
Kiakojouri, Ali
Nahvi, Mohammad Sadegh
Khazaei, Yousef
Feizi-nejad, Ali
Maghami, Mohammad Hossein
Mohammadi, Reza
Sharifshazileh, Mohammadali
Nasiri, Soraya
Akbari Boroumand, Farhad
Nadimi, Ebrahim
Rezaei, Mahmoud
Shojaei, Amir
Mirnajafi-Zadeh, Javad
Sodagar, Amir M.
author_facet Keramatzadeh, Keivan
Kiakojouri, Ali
Nahvi, Mohammad Sadegh
Khazaei, Yousef
Feizi-nejad, Ali
Maghami, Mohammad Hossein
Mohammadi, Reza
Sharifshazileh, Mohammadali
Nasiri, Soraya
Akbari Boroumand, Farhad
Nadimi, Ebrahim
Rezaei, Mahmoud
Shojaei, Amir
Mirnajafi-Zadeh, Javad
Sodagar, Amir M.
author_sort Keramatzadeh, Keivan
collection PubMed
description This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio frequency data telemetry link with 2 Mbps (partially used) data transfer rate. Encased in a 3D-printed 2.9 cm × 2.9 cm × 2.5 cm cubic package, the semi-implantable recording unit consists of a microelectrode array, a vertically-stacked PCB platform containing off-the-shelf components, and commercially-available small-size 3.7-V, 50 mAh lithium-ion batteries. Two versions of microelectrode array were developed for the recording unit: a rigid 4 × 2 microelectrode array, and a flexible 12 × 6 microelectrode array, 36 of which routed to bonding pads for actual recording. The external unit comprises a transceiver board, a data acquisition board, and a host computer, on which reconstruction of the received signals is performed. After development, assembly, and integration, the system was tested and validated in vivo on anesthetized rats. The system successfully recorded both spontaneous and evoked activities from the brain of the subject.
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spelling pubmed-77188882020-12-08 Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo Keramatzadeh, Keivan Kiakojouri, Ali Nahvi, Mohammad Sadegh Khazaei, Yousef Feizi-nejad, Ali Maghami, Mohammad Hossein Mohammadi, Reza Sharifshazileh, Mohammadali Nasiri, Soraya Akbari Boroumand, Farhad Nadimi, Ebrahim Rezaei, Mahmoud Shojaei, Amir Mirnajafi-Zadeh, Javad Sodagar, Amir M. Sci Rep Article This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio frequency data telemetry link with 2 Mbps (partially used) data transfer rate. Encased in a 3D-printed 2.9 cm × 2.9 cm × 2.5 cm cubic package, the semi-implantable recording unit consists of a microelectrode array, a vertically-stacked PCB platform containing off-the-shelf components, and commercially-available small-size 3.7-V, 50 mAh lithium-ion batteries. Two versions of microelectrode array were developed for the recording unit: a rigid 4 × 2 microelectrode array, and a flexible 12 × 6 microelectrode array, 36 of which routed to bonding pads for actual recording. The external unit comprises a transceiver board, a data acquisition board, and a host computer, on which reconstruction of the received signals is performed. After development, assembly, and integration, the system was tested and validated in vivo on anesthetized rats. The system successfully recorded both spontaneous and evoked activities from the brain of the subject. Nature Publishing Group UK 2020-12-04 /pmc/articles/PMC7718888/ /pubmed/33277523 http://dx.doi.org/10.1038/s41598-020-77953-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Keramatzadeh, Keivan
Kiakojouri, Ali
Nahvi, Mohammad Sadegh
Khazaei, Yousef
Feizi-nejad, Ali
Maghami, Mohammad Hossein
Mohammadi, Reza
Sharifshazileh, Mohammadali
Nasiri, Soraya
Akbari Boroumand, Farhad
Nadimi, Ebrahim
Rezaei, Mahmoud
Shojaei, Amir
Mirnajafi-Zadeh, Javad
Sodagar, Amir M.
Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
title Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
title_full Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
title_fullStr Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
title_full_unstemmed Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
title_short Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
title_sort wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718888/
https://www.ncbi.nlm.nih.gov/pubmed/33277523
http://dx.doi.org/10.1038/s41598-020-77953-8
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