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Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo
This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio frequency data telemetry link with 2 Mbps (p...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718888/ https://www.ncbi.nlm.nih.gov/pubmed/33277523 http://dx.doi.org/10.1038/s41598-020-77953-8 |
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author | Keramatzadeh, Keivan Kiakojouri, Ali Nahvi, Mohammad Sadegh Khazaei, Yousef Feizi-nejad, Ali Maghami, Mohammad Hossein Mohammadi, Reza Sharifshazileh, Mohammadali Nasiri, Soraya Akbari Boroumand, Farhad Nadimi, Ebrahim Rezaei, Mahmoud Shojaei, Amir Mirnajafi-Zadeh, Javad Sodagar, Amir M. |
author_facet | Keramatzadeh, Keivan Kiakojouri, Ali Nahvi, Mohammad Sadegh Khazaei, Yousef Feizi-nejad, Ali Maghami, Mohammad Hossein Mohammadi, Reza Sharifshazileh, Mohammadali Nasiri, Soraya Akbari Boroumand, Farhad Nadimi, Ebrahim Rezaei, Mahmoud Shojaei, Amir Mirnajafi-Zadeh, Javad Sodagar, Amir M. |
author_sort | Keramatzadeh, Keivan |
collection | PubMed |
description | This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio frequency data telemetry link with 2 Mbps (partially used) data transfer rate. Encased in a 3D-printed 2.9 cm × 2.9 cm × 2.5 cm cubic package, the semi-implantable recording unit consists of a microelectrode array, a vertically-stacked PCB platform containing off-the-shelf components, and commercially-available small-size 3.7-V, 50 mAh lithium-ion batteries. Two versions of microelectrode array were developed for the recording unit: a rigid 4 × 2 microelectrode array, and a flexible 12 × 6 microelectrode array, 36 of which routed to bonding pads for actual recording. The external unit comprises a transceiver board, a data acquisition board, and a host computer, on which reconstruction of the received signals is performed. After development, assembly, and integration, the system was tested and validated in vivo on anesthetized rats. The system successfully recorded both spontaneous and evoked activities from the brain of the subject. |
format | Online Article Text |
id | pubmed-7718888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77188882020-12-08 Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo Keramatzadeh, Keivan Kiakojouri, Ali Nahvi, Mohammad Sadegh Khazaei, Yousef Feizi-nejad, Ali Maghami, Mohammad Hossein Mohammadi, Reza Sharifshazileh, Mohammadali Nasiri, Soraya Akbari Boroumand, Farhad Nadimi, Ebrahim Rezaei, Mahmoud Shojaei, Amir Mirnajafi-Zadeh, Javad Sodagar, Amir M. Sci Rep Article This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio frequency data telemetry link with 2 Mbps (partially used) data transfer rate. Encased in a 3D-printed 2.9 cm × 2.9 cm × 2.5 cm cubic package, the semi-implantable recording unit consists of a microelectrode array, a vertically-stacked PCB platform containing off-the-shelf components, and commercially-available small-size 3.7-V, 50 mAh lithium-ion batteries. Two versions of microelectrode array were developed for the recording unit: a rigid 4 × 2 microelectrode array, and a flexible 12 × 6 microelectrode array, 36 of which routed to bonding pads for actual recording. The external unit comprises a transceiver board, a data acquisition board, and a host computer, on which reconstruction of the received signals is performed. After development, assembly, and integration, the system was tested and validated in vivo on anesthetized rats. The system successfully recorded both spontaneous and evoked activities from the brain of the subject. Nature Publishing Group UK 2020-12-04 /pmc/articles/PMC7718888/ /pubmed/33277523 http://dx.doi.org/10.1038/s41598-020-77953-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Keramatzadeh, Keivan Kiakojouri, Ali Nahvi, Mohammad Sadegh Khazaei, Yousef Feizi-nejad, Ali Maghami, Mohammad Hossein Mohammadi, Reza Sharifshazileh, Mohammadali Nasiri, Soraya Akbari Boroumand, Farhad Nadimi, Ebrahim Rezaei, Mahmoud Shojaei, Amir Mirnajafi-Zadeh, Javad Sodagar, Amir M. Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo |
title | Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo |
title_full | Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo |
title_fullStr | Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo |
title_full_unstemmed | Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo |
title_short | Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo |
title_sort | wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718888/ https://www.ncbi.nlm.nih.gov/pubmed/33277523 http://dx.doi.org/10.1038/s41598-020-77953-8 |
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