Cerebrospinal fluid glutamate changes in functional movement disorders

The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower i...

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Detalles Bibliográficos
Autores principales: Demartini, Benedetta, Invernizzi, Roberto William, Campiglio, Laura, Bocci, Tommaso, D’Arrigo, Andrea, Arighi, Andrea, Sciacca, Francesca, Galimberti, Daniela, Scarpini, Elio, Gambini, Orsola, Priori, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718900/
https://www.ncbi.nlm.nih.gov/pubmed/33298941
http://dx.doi.org/10.1038/s41531-020-00140-z
Descripción
Sumario:The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.

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