Cerebrospinal fluid glutamate changes in functional movement disorders

The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower i...

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Autores principales: Demartini, Benedetta, Invernizzi, Roberto William, Campiglio, Laura, Bocci, Tommaso, D’Arrigo, Andrea, Arighi, Andrea, Sciacca, Francesca, Galimberti, Daniela, Scarpini, Elio, Gambini, Orsola, Priori, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718900/
https://www.ncbi.nlm.nih.gov/pubmed/33298941
http://dx.doi.org/10.1038/s41531-020-00140-z
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author Demartini, Benedetta
Invernizzi, Roberto William
Campiglio, Laura
Bocci, Tommaso
D’Arrigo, Andrea
Arighi, Andrea
Sciacca, Francesca
Galimberti, Daniela
Scarpini, Elio
Gambini, Orsola
Priori, Alberto
author_facet Demartini, Benedetta
Invernizzi, Roberto William
Campiglio, Laura
Bocci, Tommaso
D’Arrigo, Andrea
Arighi, Andrea
Sciacca, Francesca
Galimberti, Daniela
Scarpini, Elio
Gambini, Orsola
Priori, Alberto
author_sort Demartini, Benedetta
collection PubMed
description The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.
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spelling pubmed-77189002020-12-07 Cerebrospinal fluid glutamate changes in functional movement disorders Demartini, Benedetta Invernizzi, Roberto William Campiglio, Laura Bocci, Tommaso D’Arrigo, Andrea Arighi, Andrea Sciacca, Francesca Galimberti, Daniela Scarpini, Elio Gambini, Orsola Priori, Alberto NPJ Parkinsons Dis Brief Communication The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD. Nature Publishing Group UK 2020-12-04 /pmc/articles/PMC7718900/ /pubmed/33298941 http://dx.doi.org/10.1038/s41531-020-00140-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Demartini, Benedetta
Invernizzi, Roberto William
Campiglio, Laura
Bocci, Tommaso
D’Arrigo, Andrea
Arighi, Andrea
Sciacca, Francesca
Galimberti, Daniela
Scarpini, Elio
Gambini, Orsola
Priori, Alberto
Cerebrospinal fluid glutamate changes in functional movement disorders
title Cerebrospinal fluid glutamate changes in functional movement disorders
title_full Cerebrospinal fluid glutamate changes in functional movement disorders
title_fullStr Cerebrospinal fluid glutamate changes in functional movement disorders
title_full_unstemmed Cerebrospinal fluid glutamate changes in functional movement disorders
title_short Cerebrospinal fluid glutamate changes in functional movement disorders
title_sort cerebrospinal fluid glutamate changes in functional movement disorders
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718900/
https://www.ncbi.nlm.nih.gov/pubmed/33298941
http://dx.doi.org/10.1038/s41531-020-00140-z
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