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Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus

OBJECTIVE: To evaluate the associations of serum uric acid (UA), urea nitrogen (UN), and urine specific gravity (USG) levels in the first trimester of pregnancy with the risk of gestational diabetes mellitus (GDM). PATIENTS AND METHODS: A retrospective cohort study was conducted in 1,769 pregnant wo...

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Autores principales: Li, Yan, Yu, Tingwei, Liu, Zengyou, Chen, Hengying, Liu, Yao, Wei, Yuanhuan, Sun, Ruifang, Zhang, Hongmei, Wang, Wei, Lu, Yihua, Zhou, Yingyu, Deng, Guifang, Zhang, Zheqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718966/
https://www.ncbi.nlm.nih.gov/pubmed/33293842
http://dx.doi.org/10.2147/DMSO.S282403
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author Li, Yan
Yu, Tingwei
Liu, Zengyou
Chen, Hengying
Liu, Yao
Wei, Yuanhuan
Sun, Ruifang
Zhang, Hongmei
Wang, Wei
Lu, Yihua
Zhou, Yingyu
Deng, Guifang
Zhang, Zheqing
author_facet Li, Yan
Yu, Tingwei
Liu, Zengyou
Chen, Hengying
Liu, Yao
Wei, Yuanhuan
Sun, Ruifang
Zhang, Hongmei
Wang, Wei
Lu, Yihua
Zhou, Yingyu
Deng, Guifang
Zhang, Zheqing
author_sort Li, Yan
collection PubMed
description OBJECTIVE: To evaluate the associations of serum uric acid (UA), urea nitrogen (UN), and urine specific gravity (USG) levels in the first trimester of pregnancy with the risk of gestational diabetes mellitus (GDM). PATIENTS AND METHODS: A retrospective cohort study was conducted in 1,769 pregnant women aged 31.55 ± 3.91 years. UA, UN, and USG levels were measured during the 16–18th week of gestation. GDM was diagnosed by an oral 75 g glucose tolerance test during the 24–28th week of gestation. RESULTS: A multivariate adjusted logistic regression analysis showed that UA levels in the highest quartile increased the risk of GDM by 55.7% (odds ratio [OR]: 1.557, 95% confidence interval [CI]: 1.055–2.298; p = 0.026) compared to those in the lowest quartile. USG levels in the second, third, and fourth quartiles increased the risk of GDM by 67.6% (95% CI: 1.090–2.421), 112.4% (95% CI: 1.446–3.119), and 94.5% (95% CI: 1.314–2.880), respectively, compared to those in the first quartile (p trend = 0.001). No significant association between UN levels and the GDM risk was observed. When the extreme composite biomarker score quartiles were compared, the adjusted OR (95% CI) for GDM was 1.909 (95% CI: 1.332–2.736). Age-stratified analyses revealed similar results in women aged ≤35 years only, but not in those aged >35 years. CONCLUSION: Higher levels of UA and USG and a higher composite kidney function biomarker score during the 16–18th week of gestation were positively and independently associated with an increased risk of GDM.
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spelling pubmed-77189662020-12-07 Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus Li, Yan Yu, Tingwei Liu, Zengyou Chen, Hengying Liu, Yao Wei, Yuanhuan Sun, Ruifang Zhang, Hongmei Wang, Wei Lu, Yihua Zhou, Yingyu Deng, Guifang Zhang, Zheqing Diabetes Metab Syndr Obes Original Research OBJECTIVE: To evaluate the associations of serum uric acid (UA), urea nitrogen (UN), and urine specific gravity (USG) levels in the first trimester of pregnancy with the risk of gestational diabetes mellitus (GDM). PATIENTS AND METHODS: A retrospective cohort study was conducted in 1,769 pregnant women aged 31.55 ± 3.91 years. UA, UN, and USG levels were measured during the 16–18th week of gestation. GDM was diagnosed by an oral 75 g glucose tolerance test during the 24–28th week of gestation. RESULTS: A multivariate adjusted logistic regression analysis showed that UA levels in the highest quartile increased the risk of GDM by 55.7% (odds ratio [OR]: 1.557, 95% confidence interval [CI]: 1.055–2.298; p = 0.026) compared to those in the lowest quartile. USG levels in the second, third, and fourth quartiles increased the risk of GDM by 67.6% (95% CI: 1.090–2.421), 112.4% (95% CI: 1.446–3.119), and 94.5% (95% CI: 1.314–2.880), respectively, compared to those in the first quartile (p trend = 0.001). No significant association between UN levels and the GDM risk was observed. When the extreme composite biomarker score quartiles were compared, the adjusted OR (95% CI) for GDM was 1.909 (95% CI: 1.332–2.736). Age-stratified analyses revealed similar results in women aged ≤35 years only, but not in those aged >35 years. CONCLUSION: Higher levels of UA and USG and a higher composite kidney function biomarker score during the 16–18th week of gestation were positively and independently associated with an increased risk of GDM. Dove 2020-12-01 /pmc/articles/PMC7718966/ /pubmed/33293842 http://dx.doi.org/10.2147/DMSO.S282403 Text en © 2020 Li et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Li, Yan
Yu, Tingwei
Liu, Zengyou
Chen, Hengying
Liu, Yao
Wei, Yuanhuan
Sun, Ruifang
Zhang, Hongmei
Wang, Wei
Lu, Yihua
Zhou, Yingyu
Deng, Guifang
Zhang, Zheqing
Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus
title Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus
title_full Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus
title_fullStr Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus
title_full_unstemmed Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus
title_short Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus
title_sort association of serum uric acid, urea nitrogen, and urine specific gravity levels at 16–18 weeks of gestation with the risk of gestational diabetes mellitus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7718966/
https://www.ncbi.nlm.nih.gov/pubmed/33293842
http://dx.doi.org/10.2147/DMSO.S282403
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