Cargando…

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis

Overactivation of microglia is associated with most neurodegenerative diseases. In this study we examined whether PET-measurable innate immune cell activation predicts multiple sclerosis disease progression. Activation of microglia/macrophages was measured using the 18-kDa translocator protein (TSPO...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sucksdorff, Marcus, Matilainen, Markus, Tuisku, Jouni, Polvinen, Eero, Vuorimaa, Anna, Rokka, Johanna, Nylund, Marjo, Rissanen, Eero, Airas, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719021/ https://www.ncbi.nlm.nih.gov/pubmed/33006604 http://dx.doi.org/10.1093/brain/awaa275

Ejemplares similares

Phenotyping of multiple sclerosis lesions according to innate immune cell activation using 18 kDa translocator protein-PET
por: Nylund, Marjo, et al.
Publicado: (2021)

TSPO-Detectable Chronic Active Lesions Predict Disease Progression in Multiple Sclerosis
por: Polvinen, Eero, et al.
Publicado: (2023)

Natalizumab treatment reduces microglial activation in the white matter of the MS brain
por: Sucksdorff, Marcus, et al.
Publicado: (2019)

Insights into disseminated MS brain pathology with multimodal diffusion tensor and PET imaging
por: Bezukladova, Svetlana, et al.
Publicado: (2020)

Innate Immune Cell–Related Pathology in the Thalamus Signals a Risk for Disability Progression in Multiple Sclerosis
por: Misin, Olavi, et al.
Publicado: (2022)

Imaging neuroinflammation in multiple sclerosis using TSPO-PET
por: Airas, Laura, et al.
Publicado: (2015)

High serum neurofilament associates with diffuse white matter damage in MS
por: Saraste, Maija, et al.
Publicado: (2020)

Evaluation of Microglial Activation in Multiple Sclerosis Patients Using Positron Emission Tomography
por: Airas, Laura, et al.
Publicado: (2018)

Microglial activation, white matter tract damage, and disability in MS
por: Rissanen, Eero, et al.
Publicado: (2018)

In Vivo PET Imaging of Adenosine 2A Receptors in Neuroinflammatory and Neurodegenerative Disease
por: Vuorimaa, Anna, et al.
Publicado: (2017)

Association of serum neurofilament light with microglial activation in multiple sclerosis
por: Saraste, Maija, et al.
Publicado: (2023)

Adenosine A(2A) receptor availability in patients with early- and moderate-stage Parkinson’s disease
por: Waggan, Imran, et al.
Publicado: (2022)

Effects of age, BMI and sex on the glial cell marker TSPO — a multicentre [(11)C]PBR28 HRRT PET study
por: Tuisku, Jouni, et al.
Publicado: (2019)

Insulin resistance and body mass index are associated with TSPO PET in cognitively unimpaired elderly
por: Ekblad, Laura L, et al.
Publicado: (2023)

Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
por: Kang, Yeona, et al.
Publicado: (2021)

Association of neuroinflammation with episodic memory: a [(11)C]PBR28 PET study in cognitively discordant twin pairs
por: Lindgren, Noora, et al.
Publicado: (2020)

The role of TSPO PET in assessing neuroinflammation
por: Crawshaw, Ania A., et al.
Publicado: (2017)

Supervised clustering for TSPO PET imaging
por: Schubert, Julia, et al.
Publicado: (2021)

Widespread Glial Activation in Primary Progressive Multiple Sclerosis Revealed by (18)F-PBR06 PET: A Clinically Feasible, Individualized Approach
por: Singhal, Tarun, et al.
Publicado: (2021)

(18)F-Radiolabeled Translocator Protein (TSPO) PET Tracers: Recent Development of TSPO Radioligands and Their Application to PET Study
por: Luu, Truong Giang, et al.
Publicado: (2022)

In vivo TSPO imaging in patients with multiple sclerosis: a brain PET study with [(18)F]FEDAA1106
por: Takano, Akihiro, et al.
Publicado: (2013)

TSPO imaging using the novel PET ligand [(18)F]GE-180: quantification approaches in patients with multiple sclerosis
por: Vomacka, Lena, et al.
Publicado: (2017)

PET Imaging of Microglial Activation—Beyond Targeting TSPO
por: Janssen, Bieneke, et al.
Publicado: (2018)

Recent developments on PET radiotracers for TSPO and their applications in neuroimaging
por: Zhang, Lingling, et al.
Publicado: (2021)

Identifying improved TSPO PET imaging probes through biomathematics: The impact of multiple TSPO binding sites in vivo
por: Guo, Qi, et al.
Publicado: (2012)

TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy
por: Bertoglio, Daniele, et al.
Publicado: (2021)

Employment at the onset of partial disability retirement and four years later
por: Polvinen, A
Publicado: (2022)

Extension of microglial activation is associated with epilepsy and cognitive dysfunction in Tuberous sclerosis complex: A TSPO-PET study
por: Kagitani-Shimono, Kuriko, et al.
Publicado: (2022)

Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis
por: De Picker, Livia, et al.
Publicado: (2020)

Kinetic modeling and parameter estimation of TSPO PET imaging in the human brain
por: Wimberley, Catriona, et al.
Publicado: (2021)

Tissue probability-based AC for neurological PET/MR using SPM8
por: Teuho, Jarmo, et al.
Publicado: (2015)

A TSPO ligand is protective in a mouse model of multiple sclerosis
por: Daugherty, Daniel J, et al.
Publicado: (2013)

PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects
por: Richards, Erica M., et al.
Publicado: (2018)

TSPO PET Imaging: From Microglial Activation to Peripheral Sterile Inflammatory Diseases?
por: Largeau, Bérenger, et al.
Publicado: (2017)

Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders
por: Werry, Eryn L., et al.
Publicado: (2019)

Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function
por: Veronese, Mattia, et al.
Publicado: (2021)

Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease
por: Tournier, Benjamin B., et al.
Publicado: (2020)

Differential Spatial Distribution of TSPO or Amino Acid PET Signal and MRI Contrast Enhancement in Gliomas
por: Kaiser, Lena, et al.
Publicado: (2021)

TSPO PET signal using [(18)F]GE180 is associated with survival in recurrent gliomas
por: Quach, Stefanie, et al.
Publicado: (2022)

Prognostic Value of TSPO PET Before Radiotherapy in Newly Diagnosed IDH–Wild-Type Glioblastoma
por: Albert, Nathalie L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lrsuqm0ual80o6blmbv1kbunfq