Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells

Intensive chemotherapy for acute leukemia can usually induce complete remission, but fails in many patients to eradicate the leukemia stem cells responsible for relapse. There is accumulating evidence that these relapse-inducing cells are maintained and protected by signals provided by the microenvi...

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Detalles Bibliográficos
Autores principales: Tremblay, Cedric S., Chiu, Sung Kai, Saw, Jesslyn, McCalmont, Hannah, Litalien, Veronique, Boyle, Jacqueline, Sonderegger, Stefan E., Chau, Ngoc, Evans, Kathryn, Cerruti, Loretta, Salmon, Jessica M., McCluskey, Adam, Lock, Richard B., Robinson, Phillip J., Jane, Stephen M., Curtis, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719179/
https://www.ncbi.nlm.nih.gov/pubmed/33277497
http://dx.doi.org/10.1038/s41467-020-20091-6

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